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mltA membrane-bound lytic murein transglycosylase A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944964, updated on 4-Feb-2024

Summary

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Gene symbol
mltA
Gene description
membrane-bound lytic murein transglycosylase A
Primary source
ASAP:ABE-0009228
Locus tag
b2813
See related
ECOCYC:G7457
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2809; mlt; ygdM
Summary
MltA cleaves the glycosidic bonds between the N-acetylmuramic acid and N-acetylglucosamine residues in murein. [More information is available at EcoGene: EG13085]. MltA is one of six (along with MltB, MltC, MltD, EmtA, and Slt70) major lytic endotransglycosylases expressed in Escherichia coli. [More information is available at EcoCyc: G7457].
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Genomic context

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Sequence:
NC_000913.3 (2946081..2947178, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cysteine sulfinate desulfinase Neighboring gene sulfur acceptor protein CsdE Neighboring gene tRNA threonylcarbamoyladenosine dehydratase Neighboring gene tRNA-Met Neighboring gene tRNA-Met

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of Escherichia coli Lytic transglycosylase MltA with bound chitohexaose: implications for peptidoglycan binding and cleavage. van Straaten KE, et al. J Biol Chem, 2007 Jul 20. PMID 17502382
  2. Crystal structures of the lytic transglycosylase MltA from N.gonorrhoeae and E.coli: insights into interdomain movements and substrate binding. Powell AJ, et al. J Mol Biol, 2006 May 26. PMID 16618494
  3. Escherichia coli MltA: MAD phasing and refinement of a tetartohedrally twinned protein crystal structure. Barends TR, et al. Acta Crystallogr D Biol Crystallogr, 2005 May. PMID 15858272
  4. Purification, crystallization and preliminary X-ray analysis of the lytic transglycosylase MltA from Escherichia coli. Van Straaten KE, et al. Acta Crystallogr D Biol Crystallogr, 2004 Apr. PMID 15039577
  5. Purification and properties of a membrane-bound lytic transglycosylase from Escherichia coli. Ursinus A, et al. J Bacteriol, 1994 Jan. PMID 8288527, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. crystallographic analysis of Escherichia coli Lytic transglycosylase MltA with bound chitohexaose
    Title: Structure of Escherichia coli Lytic transglycosylase MltA with bound chitohexaose: implications for peptidoglycan binding and cleavage.
  2. The crystal structure of the lytic transglycosylase MltA from Escherichia coli without a membrane anchor was solved at 2.0A resolution.
    Title: Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold.
  3. Results describe the crystal structures of MltA from Neisseria gonorrhoeae and Escherichia coli.
    Title: Crystal structures of the lytic transglycosylase MltA from N.gonorrhoeae and E.coli: insights into interdomain movements and substrate binding.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lytic transglycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lytic transglycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidoglycan catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidoglycan turnover IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane-bounded periplasmic space TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
membrane-bound lytic murein transglycosylase A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2946081..2947178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417293.1 membrane-bound lytic murein transglycosylase A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417293.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3R0MT56, A0A8T5YBU5
    Conserved Domains (1) summary
    PRK11162
    Location:1 → 354
    mltA; murein transglycosylase A; Provisional
Nucleotide Protein
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