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solA N-methyl-L-tryptophan oxidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944983, updated on 4-Apr-2024

Summary

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Gene symbol
solA
Gene description
N-methyl-L-tryptophan oxidase
Primary source
ASAP:ABE-0003590
Locus tag
b1059
See related
ECOCYC:G6556
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1044
Summary
SolA has weak activity on carbinolamines, sarcosine and other secondary amino acids. [More information is available at EcoGene: EG12669]. The solA gene product has N-methyltryptophan oxidase (MTOX) activity. [More information is available at EcoCyc: G6556].
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Genomic context

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Sequence:
NC_000913.3 (1119468..1120586, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative cytochrome b561 YceJ Neighboring gene DUF2770 domain-containing protein YceO Neighboring gene regulator of biofilm formation Neighboring gene DNA damage-inducible protein I

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pleiotropic impact of a single lysine mutation on biosynthesis of and catalysis by N-methyltryptophan oxidase. Bruckner RC, et al. Biochemistry, 2011 Jun 7. PMID 21526853, Free PMC Article
  2. The X-ray structure of N-methyltryptophan oxidase reveals the structural determinants of substrate specificity. Ilari A, et al. Proteins, 2008 Jun. PMID 18186483
  3. pH and kinetic isotope effects on sarcosine oxidation by N-methyltryptophan oxidase. Ralph EC, et al. Biochemistry, 2005 Mar 1. PMID 15723552, Free PMC Article
  4. Tautomeric rearrangement of a dihydroflavin bound to monomeric sarcosine oxidase or N-methyltryptophan oxidase. Khanna P, et al. Biochemistry, 2003 Feb 4. PMID 12549903
  5. N-methyltryptophan oxidase from Escherichia coli: reaction kinetics with N-methyl amino acid and carbinolamine substrates. Khanna P, et al. Biochemistry, 2001 Feb 6. PMID 11170473

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lys259 is the site of oxygen activation in MTOX and also plays a role in holoenzyme biosynthesis and N-methyltryptophan oxidation
    Title: Pleiotropic impact of a single lysine mutation on biosynthesis of and catalysis by N-methyltryptophan oxidase.
  2. an examination of kinetic properties and substrate specificity.an examination of kinetic properties and substrate specificity.
    Title: pH and kinetic isotope effects on sarcosine oxidation by N-methyltryptophan oxidase.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables N-methyl-L-amino-acid oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-methyl-L-amino-acid oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables sarcosine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
N-methyl-L-tryptophan oxidase
NP_415577.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1119468..1120586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415577.1 N-methyl-L-tryptophan oxidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415577.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AA87EVJ4
    Conserved Domains (1) summary
    PRK11259
    Location:1 → 372
    solA; N-methyl-L-tryptophan oxidase
Nucleotide Protein
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