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pyrH UMP kinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944989, updated on 23-Nov-2023

Summary

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Gene symbol
pyrH
Gene description
UMP kinase
Primary source
ASAP:ABE-0000582
Locus tag
b0171
See related
ECOCYC:EG11539
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0170; smbA; umk
Summary
Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11539]. Expression of uridylate kinase is essential for growth of Escherichia coli . [More information is available at EcoCyc: EG11539].
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Genomic context

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Sequence:
NC_000913.3 (191855..192580)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 30S ribosomal subunit protein S2 Neighboring gene protein chain elongation factor EF-Ts Neighboring gene ribosome-recycling factor Neighboring gene 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The site for the allosteric activator GTP of Escherichia coli UMP kinase. Marco-Marín C, et al. FEBS Lett, 2009 Jan 5. PMID 19071117
  2. Structural and functional characterization of Escherichia coli UMP kinase in complex with its allosteric regulator GTP. Meyer P, et al. J Biol Chem, 2008 Dec 19. PMID 18945668
  3. Structure-function relationships of UMP kinases from pyrH mutants of Gram-negative bacteria. Sakamoto H, et al. Microbiology (Reading), 2004 Jul. PMID 15256558
  4. Comparative modelling and immunochemical reactivity of Escherichia coli UMP kinase. Labesse G, et al. Biochem Biophys Res Commun, 2002 May 31. PMID 12054759
  5. Immunochemical analysis of UMP kinase from Escherichia coli. Landais S, et al. J Bacteriol, 1999 Feb. PMID 9922246, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Escherichia coli UMP-kinase, a member of the aspartokinase family, is a hexamer regulated by guanine nucleotides and UTP.
  2. cross-talk mechanism between enzyme subunits involved in cooperative binding at the phosphate acceptor site and in allosteric regulation by GTP
    Title: Structure of Escherichia coli UMP kinase differs from that of other nucleoside monophosphate kinases and sheds new light on enzyme regulation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables UMP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UMP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UMP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables UMP/dUMP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pyrimidine nucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
UMP kinase
NP_414713.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    191855..192580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414713.1 UMP kinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414713.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1NBT4
    Conserved Domains (1) summary
    cd04254
    Location:10 → 240
    AAK_UMPK-PyrH-Ec; UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and ...
Nucleotide Protein
Heading Accession and Version

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