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mhpE 4-hydroxy-2-oxovalerate aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945012, updated on 2-May-2024

Summary

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Gene symbol
mhpE
Gene description
4-hydroxy-2-oxovalerate aldolase
Primary source
ASAP:ABE-0001209
Locus tag
b0352
See related
ECOCYC:G6205
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0349
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Genomic context

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Sequence:
NC_000913.3 (373868..374881)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase Neighboring gene 2-hydroxypentadienoate hydratase Neighboring gene acetaldehyde dehydrogenase (acetylating) MhpF Neighboring gene 3-hydroxyphenylpropionate/3-hydroxycinnamate:H(+) symporter Neighboring gene DUF2058 domain-containing protein YaiL

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Substrate selectivity and biochemical properties of 4-hydroxy-2-keto-pentanoic acid aldolase from Escherichia coli. Pollard JR, et al. Appl Environ Microbiol, 1998 Oct. PMID 9758851, Free PMC Article
  2. Stereospecificity in meta-fission catabolic pathways. Burlingame R, et al. J Bacteriol, 1983 Jul. PMID 6345511, Free PMC Article
  3. Overproduction, purification and properties of 2,3-dihydroxyphenylpropionate 1,2-dioxygenase from Escherichia coli. Bugg TD. Biochim Biophys Acta, 1993 Oct 6. PMID 8399388
  4. Coupled expression of MhpE aldolase and MhpF dehydrogenase in Escherichia coli. Lee SJ, et al. Biochem Biophys Res Commun, 2006 Aug 4. PMID 16782065
  5. Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli. Burlingame R, et al. J Bacteriol, 1983 Jul. PMID 6345502, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. expression of mhpE occurs only when MhpF is available for the formation of a complex
    Title: Coupled expression of MhpE aldolase and MhpF dehydrogenase in Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2-isopropylmalate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-hydroxy-2-oxovalerate aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-hydroxy-2-oxovalerate aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3-phenylpropionate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-leucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in catabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
4-hydroxy-2-oxovalerate aldolase
NP_414886.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    373868..374881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414886.1 4-hydroxy-2-oxovalerate aldolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414886.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AA94MB09
    Conserved Domains (1) summary
    PRK08195
    Location:3 → 333
    PRK08195; 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated
Nucleotide Protein
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