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proC pyrroline-5-carboxylate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945034, updated on 2-May-2024

Summary

Gene symbol
proC
Gene description
pyrroline-5-carboxylate reductase
Primary source
ASAP:ABE-0001338
Locus tag
b0386
See related
ECOCYC:EG10769
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0381; pro(3); Pro2; pro3
Summary
Pyrroline-5-carboxylate-reductase (ProC) catalyzes the last step in proline biosynthesis. [More information is available at EcoCyc: EG10769].
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Genomic context

Sequence:
NC_000913.3 (404835..405644, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphate starvation-inducible protein PsiF Neighboring gene diguanylate cyclase DgcC Neighboring gene DUF188 domain-containing protein YaiI Neighboring gene shikimate kinase 2

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables pyrroline-5-carboxylate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pyrroline-5-carboxylate reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pyrroline-5-carboxylate reductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in L-proline biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pyrroline-5-carboxylate reductase
NP_414920.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    404835..405644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414920.1 pyrroline-5-carboxylate reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414920.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A826TF48, A0A8S7CMM4
    Conserved Domains (1) summary
    PRK11880
    Location:1269
    PRK11880; pyrroline-5-carboxylate reductase; Reviewed