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betT choline:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945079, updated on 4-Apr-2024

Summary

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Gene symbol
betT
Gene description
choline:H(+) symporter
Primary source
ASAP:ABE-0001080
Locus tag
b0314
See related
ECOCYC:EG10112
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0312
Summary
The bet genes are induced by choline, oxygen, and osmotic stress. [More information is available at EcoGene: EG10112]. BetT is a proton-motive-force-driven choline transporter that belongs to the Betaine Carnitine Choline Transport (BCCT) family of proteins. [More information is available at EcoCyc: EG10112].
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Genomic context

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Sequence:
NC_000913.3 (329463..331496)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene betaine aldehyde dehydrogenase Neighboring gene DNA-binding transcriptional repressor BetI Neighboring gene protein YahV Neighboring gene DNA-binding transcriptional regulator/c-di-GMP phosphodiesterase PdeL

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. lac fusion analysis of the bet genes of Escherichia coli: regulation by osmolarity, temperature, oxygen, choline, and glycine betaine. Eshoo MW. J Bacteriol, 1988 Nov. PMID 3141381, Free PMC Article
  2. DNA-binding properties of the BetI repressor protein of Escherichia coli: the inducer choline stimulates BetI-DNA complex formation. Rkenes TP, et al. J Bacteriol, 1996 Mar. PMID 8626295, Free PMC Article
  3. The complex bet promoters of Escherichia coli: regulation by oxygen (ArcA), choline (BetI), and osmotic stress. Lamark T, et al. J Bacteriol, 1996 Mar. PMID 8626294, Free PMC Article
  4. DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli. Lamark T, et al. Mol Microbiol, 1991 May. PMID 1956285
  5. Membrane topology and mutational analysis of the osmotically activated BetT choline transporter of Escherichia coli. Tøndervik A, et al. Microbiology (Reading), 2007 Mar. PMID 17322201

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glycine betaine biosynthetic process from choline IEA
Inferred from Electronic Annotation
more info
  
involved_in nitrogen compound transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
choline:H(+) symporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    329463..331496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414848.1 choline:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414848.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7TU02, A0AA43PV56
    Conserved Domains (1) summary
    PRK09928
    Location:1 → 677
    PRK09928; choline transport protein BetT; Provisional
Nucleotide Protein
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