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apt adenine phosphoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945113, updated on 4-Apr-2024

Summary

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Gene symbol
apt
Gene description
adenine phosphoribosyltransferase
Primary source
ASAP:ABE-0001628
Locus tag
b0469
See related
ECOCYC:EG10051
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0463
Summary
Adenine phosphoribosyltransferase is one of the purine salvage enzymes which play an important role in maintaining nucleotide pool balance in Escherichia coli. [More information is available at EcoCyc: EG10051].
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Genomic context

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Sequence:
NC_000913.3 (491412..491963)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene primosomal replication protein N'' Neighboring gene DUF454 domain-containing inner membrane protein YbaN Neighboring gene DNA polymerase III subunit gamma;DNA polymerase III subunit tau Neighboring gene putative nucleoid-associated protein YbaB Neighboring gene recombination mediator protein RecR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and restriction map of the E. coli apt gene. Hershey HV, et al. Gene, 1982 Jul-Aug. PMID 6292052
  2. Adenine phosphoribosyltransferase in Mycoplasma mycoides and Escherichia coli. Sin IL, et al. J Bacteriol, 1972 Oct. PMID 4562405, Free PMC Article
  3. The regulation of purine utilization in bacteria. II. Adenine phosphoribosyltransferase in isolated membrane preparations and its role in transport of adenine across the membrane. Hochstadt-Ozer J, et al. J Biol Chem, 1971 Sep 10. PMID 4328694
  4. The regulation of purine utilization in bacteria. I. Purification of adenine phosphoribosyltransferase from Escherichia coli K12 and control of activity by nucleotides. Hochstadt-Ozer J, et al. J Biol Chem, 1971 Sep 10. PMID 4328693
  5. [Phenotypic manifestation of mutations involving resistance to 2,6-diaminopurine (apt) in the genome of purine auxotrophs of Escherichia coli K-12]. Kocharian ShM, et al. Genetika, 1976. PMID 793927

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Multi-enzyme Cascade for the Biosynthesis of AICA Ribonucleoside Di- and Triphosphate.
    Title: A Multi-enzyme Cascade for the Biosynthesis of AICA Ribonucleoside Di- and Triphosphate.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Oligoribonuclease is encoded by a highly conserved gene in the 3'-5' exonuclease superfamily.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables adenine phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenine phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenine phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in AMP salvage IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within AMP salvage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenine salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine ribonucleoside salvage IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenine phosphoribosyltransferase
NP_415002.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    491412..491963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415002.1 adenine phosphoribosyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415002.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9A9Q2
    Conserved Domains (1) summary
    PRK02304
    Location:6 → 182
    PRK02304; adenine phosphoribosyltransferase; Provisional
Nucleotide Protein
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Other Literature Sources
Molecular Biology Databases
Research Materials