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hybC hydrogenase 2 large subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945182, updated on 25-Jan-2024

Summary

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Gene symbol
hybC
Gene description
hydrogenase 2 large subunit
Primary source
ASAP:ABE-0009828
Locus tag
b2994
See related
ECOCYC:EG11801
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2988
Summary
HybC is co-exported bound to TAT substrate HybO. [More information is available at EcoGene: EG11801]. HybC is the large subunit of hydrogenase 2. [More information is available at EcoCyc: EG11801].
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Genomic context

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Sequence:
NC_000913.3 (3141286..3142989, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase maturation factor HybG Neighboring gene hydrogenase maturation protein HybF Neighboring gene hydrogenase 2-specific chaperone Neighboring gene hydrogenase 2 maturation protease Neighboring gene hydrogenase 2 membrane subunit Neighboring gene hydrogenase 2 iron-sulfur protein Neighboring gene hydrogenase 2 small subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a variant of the hydrogenase 2 large subunit, HybC, containing a fused C-terminal pentapeptide, was isolated.
    Title: Evidence for an oxygen-sensitive iron-sulfur cluster in an immature large subunit species of Escherichia coli [NiFe]-hydrogenase 2.
  2. Hydrogen-dependent reduction of benzyl viologen in hydrogenases HyaB, HybC and HybE is dependent on the [Fe-S]-cluster-containing small subunit.
    Title: Efficient electron transfer from hydrogen to benzyl viologen by the [NiFe]-hydrogenases of Escherichia coli is dependent on the coexpression of the iron-sulfur cluster-containing small subunit.
  3. Studies indicate that Hyd-1 and Hyd-2 are two H(2) uptake enzymes, while Hyd-1 is encoded by the first two genes of the hyaABCDEF operon, hyaA and hyaB, Hyd-2 is encoded by genes hybO and hybC of the hybOABCDEFG operon.
    Title: How Escherichia coli is equipped to oxidize hydrogen under different redox conditions.
  4. N-terminus verified by Edman degradation on mature peptide
    Title: Reassignment of the gene encoding the Escherichia coli hydrogenase 2 small subunit--identification of a soluble precursor of the small subunit in a hypB mutant.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ferredoxin hydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrogenase (acceptor) activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nickel cation binding IEA
Inferred from Electronic Annotation
more info
  
enables nickel cation binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hydrogenase 2 large subunit
NP_417468.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3141286..3142989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417468.1 hydrogenase 2 large subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417468.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9QER0, A0A7L5VC01, A0A8S7E9J3
    Conserved Domains (1) summary
    PRK10467
    Location:1 → 567
    PRK10467; hydrogenase 2 large subunit; Provisional
Nucleotide Protein
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Gene LinkOut

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