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glf UDP-galactopyranose mutase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945235, updated on 23-Nov-2023

Summary

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Gene symbol
glf
Gene description
UDP-galactopyranose mutase
Primary source
ASAP:ABE-0006755
Locus tag
b2036
See related
ECOCYC:EG11981
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2030; yefE
Summary
UDP-D-galactopyranose mutase catalyzes the reversible interconversion of UDP-galactopyranose and UDP-galactofuranose . [More information is available at EcoCyc: EG11981].
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Genomic context

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Sequence:
NC_000913.3 (2107226..2108329, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ Neighboring gene beta-1,6-galactofuranosyltransferase WbbI Neighboring gene putative O-antigen polymerase Neighboring gene polyisoprenol-linked O16-antigen repeat unit flippase Neighboring gene dTDP-4-dehydrorhamnose 3,5-epimerase Neighboring gene glucose-1-phosphate thymidylyltransferase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Convergent and stereoselective synthesis of iminosugar-containing Galf and UDP-Galf mimicks: evaluation as inhibitors of UDP-Gal mutase. Liautard V, et al. J Org Chem, 2008 Apr 18. PMID 18358048
  2. Stereoselective synthesis of beta-1-C-substituted 1,4-dideoxy-1,4-imino-D-galactitols and evaluation as UDP-galactopyranose mutase inhibitors. Desvergnes S, et al. Bioorg Med Chem, 2007 Oct 1. PMID 17662609
  3. Reconstitution of UDP-galactopyranose mutase with 1-deaza-FAD and 5-deaza-FAD: analysis and mechanistic implications. Huang Z, et al. Bioorg Chem, 2003 Dec. PMID 14613770
  4. UDP-galactopyranose mutase has a novel structure and mechanism. Sanders DA, et al. Nat Struct Biol, 2001 Oct. PMID 11573090
  5. Mechanistic investigation of UDP-galactopyranose mutase from Escherichia coli using 2- and 3-fluorinated UDP-galactofuranose as probes. Zhang Q, et al. J Am Chem Soc, 2001 Jul 18. PMID 11448178

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Galactofuranose biosynthesis in Escherichia coli K-12: identification and cloning of UDP-galactopyranose mutase.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables UDP-galactopyranose mutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-galactopyranose mutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-galactopyranose mutase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
UDP-galactopyranose mutase
NP_416540.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2107226..2108329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416540.1 UDP-galactopyranose mutase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416540.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P37747
    Conserved Domains (1) summary
    COG0562
    Location:1 → 367
    Glf; UDP-galactopyranose mutase [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
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