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nadD nicotinate-nucleotide adenylyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945248, updated on 23-Nov-2023

Summary

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Gene symbol
nadD
Gene description
nicotinate-nucleotide adenylyltransferase
Primary source
ASAP:ABE-0002187
Locus tag
b0639
See related
ECOCYC:G6350
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0632; fusB; ybeN
Summary
Nicotinate-mononucleotide adenylyltransferase is an essential enzyme involved in both de novo biosynthesis and salvage of NAD+ and NADPH. [More information is available at EcoCyc: G6350].
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Genomic context

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Sequence:
NC_000913.3 (669931..670572, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ribosomal silencing factor RsfS Neighboring gene putative adenosylcobalamin phosphatase/alpha-ribazole phosphatase Neighboring gene DNA polymerase III subunit delta Neighboring gene lipopolysaccharide assembly protein LptE Neighboring gene leucine--tRNA ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Engineering Escherichia coli Nicotinic Acid Mononucleotide Adenylyltransferase for Fully Active Amidated NAD Biosynthesis. Wang X, et al. Appl Environ Microbiol, 2017 Jul 1. PMID 28455340, Free PMC Article
  2. Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD. Sorci L, et al. Chem Biol, 2009 Aug 28. PMID 19716475, Free PMC Article
  3. Analysis of Escherichia coli nicotinate mononucleotide adenylyltransferase mutants in vivo and in vitro. Stancek M, et al. BMC Biochem, 2005 Sep 9. PMID 16153292, Free PMC Article
  4. fusB is an allele of nadD, encoding nicotinate mononucleotide adenylyltransferase in Escherichia coli. Stancek M, et al. Microbiology (Reading), 2003 Sep. PMID 12949168
  5. Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD. Zhang H, et al. Structure, 2002 Jan. PMID 11796112

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutation of Y84V/Y118D and A86W/Y118N of NadD resulted in a high preference for nicotinamide mononucleotide.
    Title: Engineering Escherichia coli Nicotinic Acid Mononucleotide Adenylyltransferase for Fully Active Amidated NAD Biosynthesis.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables nicotinamide-nucleotide adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinate-nucleotide adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinate-nucleotide adenylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nicotinate-nucleotide adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within 'de novo' NAD biosynthetic process from aspartate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in NAD biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within NAD salvage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyridine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nicotinate-nucleotide adenylyltransferase
NP_415172.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    669931..670572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415172.1 nicotinate-nucleotide adenylyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415172.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    W1WYY9
    Conserved Domains (1) summary
    PRK00071
    Location:1 → 213
    nadD; nicotinate-nucleotide adenylyltransferase
Nucleotide Protein
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