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entA 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945284, updated on 4-Apr-2024

Summary

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Gene symbol
entA
Gene description
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
Primary source
ASAP:ABE-0002054
Locus tag
b0596
See related
ECOCYC:EG10259
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0589
Summary
2,3-Dihydro-2,3-dihydroxybenzoate dehydrogenase catalyzes the formation of 2,3-dihydroxybenzoate (DHB), an intermediate in the enterobactin biosynthesis pathway. [More information is available at EcoCyc: EG10259].
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Genomic context

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Sequence:
NC_000913.3 (628551..629297)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene isochorismate synthase EntC Neighboring gene 2,3-dihydroxybenzoate-AMP ligase Neighboring gene enterobactin synthase component B Neighboring gene proofreading thioesterase in enterobactin biosynthesis Neighboring gene pyruvate transporter CstA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Determination of the crystal structure of EntA, a 2,3-dihydro-2,3-dihydroxybenzoic acid dehydrogenase from Escherichia coli. Sundlov JA, et al. Acta Crystallogr D Biol Crystallogr, 2006 Jul. PMID 16790929
  2. Mechanistic studies on trans-2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (Ent A) in the biosynthesis of the iron chelator enterobactin. Sakaitani M, et al. Biochemistry, 1990 Jul 24. PMID 2144454
  3. Biosynthesis of the iron-transport compound enterochelin: mutants of Escherichia coli unable to synthesize 2,3-dihydroxybenzoate. Young IG, et al. J Bacteriol, 1971 Apr. PMID 4928016, Free PMC Article
  4. Nucleotide sequence of the Escherichia coli entE gene. Staab JF, et al. FEMS Microbiol Lett, 1989 May. PMID 2525505
  5. Role of enterobactin and intracellular iron in cell lethality during near-UV irradiation in Escherichia coli. Hoerter J, et al. Photochem Photobiol, 1996 Sep. PMID 8806229

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Nucleotide sequence of a cluster of Escherichia coli enterobactin biosynthesis genes: identification of entA and purification of its product 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in enterobactin biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in enterobactin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within enterobactin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in siderophore biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
NP_415128.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    628551..629297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415128.1 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415128.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AKU0, A0A827YAY8, A0A8T5ZEM7
    Conserved Domains (1) summary
    PRK08220
    Location:1 → 248
    PRK08220; 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated
Nucleotide Protein
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Gene LinkOut

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