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fldA flavodoxin 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945293, updated on 11-Apr-2024

Summary

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Gene symbol
fldA
Gene description
flavodoxin 1
Primary source
ASAP:ABE-0002332
Locus tag
b0684
See related
ECOCYC:EG10318
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0672
Summary
Essential gene. [More information is available at EcoGene: EG10318]. Flavodoxins are small, acidic electron transfer proteins which contain FMN as a prosthetic group. [More information is available at EcoCyc: EG10318].
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Genomic context

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Sequence:
NC_000913.3 (710935..711465, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipoprotein ChiQ Neighboring gene DNA-binding transcriptional dual regulator Fur Neighboring gene RyhB-regulated fur leader peptide Neighboring gene ribbon-helix-helix domain-containing protein YbfE Neighboring gene esterase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A flavodoxin that is required for enzyme activation: the structure of oxidized flavodoxin from Escherichia coli at 1.8 A resolution. Hoover DM, et al. Protein Sci, 1997 Dec. PMID 9416602, Free PMC Article
  2. NMR assignments, secondary structure and hydration of oxidized Escherichia coli flavodoxin. Ponstingl H, et al. Eur J Biochem, 1997 Mar 1. PMID 9119004
  3. The interaction of NADPH-P450 reductase with P450: an electrochemical study of the role of the flavin mononucleotide-binding domain. Estabrook RW, et al. Arch Biochem Biophys, 1996 Sep 1. PMID 8806785
  4. Flavodoxin is required for the activation of the anaerobic ribonucleotide reductase. Bianchi V, et al. Biochem Biophys Res Commun, 1993 Dec 15. PMID 8267617
  5. Interaction of flavodoxin with cobalamin-dependent methionine synthase. Hall DA, et al. Biochemistry, 2000 Sep 5. PMID 10978155

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Flavodoxin and NADPH-flavodoxin reductase from Escherichia coli support bovine cytochrome P450c17 hydroxylase activities.
  2. The essential role for flavodoxin I in E. coli is in the MEP pathway for isoprenoid biosynthesis.
    Title: fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
flavodoxin 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    710935..711465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415210.1 flavodoxin 1 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415210.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ADE9
    Conserved Domains (1) summary
    PRK09267
    Location:1 → 170
    PRK09267; flavodoxin FldA; Validated
Nucleotide Protein
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Gene LinkOut

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