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sucA subunit of E1(0) component of 2-oxoglutarate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945303, updated on 4-Apr-2024

Summary

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Gene symbol
sucA
Gene description
subunit of E1(0) component of 2-oxoglutarate dehydrogenase
Primary source
ASAP:ABE-0002478
Locus tag
b0726
See related
ECOCYC:EG10979
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0714; lys+met
Summary
sucAB is a synthetic lethal with sucCD. [More information is available at EcoGene: EG10979]. SucA is the E1(0) component of the oxoglutarate dehydrogenase complex. [More information is available at EcoCyc: EG10979].
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Genomic context

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Sequence:
NC_000913.3 (758706..761507)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene succinate:quinone oxidoreductase, membrane protein SdhD Neighboring gene succinate:quinone oxidoreductase, FAD binding protein Neighboring gene succinate:quinone oxidoreductase, iron-sulfur cluster binding protein Neighboring gene dihydrolipoyltranssuccinylase Neighboring gene succinyl-CoA synthetase subunit beta Neighboring gene succinyl-CoA synthetase subunit alpha

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alpha-keto acid dehydrogenase complexes. XIX. Subunit structure of the Escherichia coli alpha-ketoglutarate dehydrogenase complex. Pettit FH, et al. J Biol Chem, 1973 Aug 10. PMID 4588679
  2. Off-pathway, oxygen-dependent thiamine radical in the Krebs cycle. Frank RA, et al. J Am Chem Soc, 2008 Feb 6. PMID 18183975, Free PMC Article
  3. Crystal structure of the E1 component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex. Frank RA, et al. J Mol Biol, 2007 May 4. PMID 17367808, Free PMC Article
  4. Nucleotide sequence of the sucA gene encoding the 2-oxoglutarate dehydrogenase of Escherichia coli K12. Darlison MG, et al. Eur J Biochem, 1984 Jun 1. PMID 6376123
  5. Molecular cloning of four tricarboxylic acid cyclic genes of Escherichia coli. Spencer ME, et al. J Bacteriol, 1982 Aug. PMID 6284701, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables oxoglutarate dehydrogenase (succinyl-transferring) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxoglutarate dehydrogenase (succinyl-transferring) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxoglutarate dehydrogenase (succinyl-transferring) activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thiamine pyrophosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables thiamine pyrophosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of oxoglutarate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oxoglutarate dehydrogenase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
subunit of E1(0) component of 2-oxoglutarate dehydrogenase
NP_415254.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    758706..761507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415254.1 subunit of E1(0) component of 2-oxoglutarate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415254.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376DDS9, A0A3W4K299, A0A828PKS4, A0A8S7IU72, A0A8S7XUH2, A0A8T3UK27
    Conserved Domains (1) summary
    PRK09404
    Location:2 → 931
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
Nucleotide Protein
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