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sucB dihydrolipoyltranssuccinylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945307, updated on 2-May-2024

Summary

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Gene symbol
sucB
Gene description
dihydrolipoyltranssuccinylase
Primary source
ASAP:ABE-0002480
Locus tag
b0727
See related
ECOCYC:EG10980
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0715
Summary
sucAB is a synthetic lethal with sucCD. [More information is available at EcoGene: EG10980]. The SucB subunit (E2o) of the 2-oxoglutarate dehydrogenase complex is responsible for the dihydrolipoamide succinyltransferase activity . [More information is available at EcoCyc: EG10980].
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Genomic context

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Sequence:
NC_000913.3 (761522..762739)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene succinate:quinone oxidoreductase, iron-sulfur cluster binding protein Neighboring gene subunit of E1(0) component of 2-oxoglutarate dehydrogenase Neighboring gene succinyl-CoA synthetase subunit beta Neighboring gene succinyl-CoA synthetase subunit alpha

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. All-atom replica exchange molecular simulation of protein BBL. Zhang J, et al. Proteins, 2008 Aug 15. PMID 18320591
  2. Experimental identification of downhill protein folding. Garcia-Mira MM, et al. Science, 2002 Dec 13. PMID 12481137
  3. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Bryk R, et al. Science, 2002 Feb 8. PMID 11799204
  4. Characterization of the Coxiella burnetti sucB gene encoding an immunogenic dihydrolipoamide succinyltransferase. Nguyen SV, et al. Microbiol Immunol, 1999. PMID 10524791
  5. Crystal structure of the truncated cubic core component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex. Knapp JE, et al. J Mol Biol, 1998 Jul 24. PMID 9677295

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. sucB and ubiF mutants deficient in energy production were identified from the mutant screens to have defective persister survival as demonstrated by higher susceptibility to various antibiotics and different stresses.
    Title: Energy production genes sucB and ubiF are involved in persister survival and tolerance to multiple antibiotics and stresses in Escherichia coli.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  3. sucAB and sucCD are mutually essential genes for production of succinyl Coa that is essential for cell viability
    Title: sucAB and sucCD are mutually essential genes in Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydrolipoyllysine-residue succinyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydrolipoyllysine-residue succinyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydrolipoyllysine-residue succinyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydrolipoyllysine-residue succinyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lipoic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-lysine catabolic process to acetyl-CoA via saccharopine IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tricarboxylic acid cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of oxoglutarate dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of oxoglutarate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
  
part_of oxoglutarate dehydrogenase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
dihydrolipoyltranssuccinylase
NP_415255.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    761522..762739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415255.1 dihydrolipoyltranssuccinylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415255.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A418H168, A0A6C9QAQ1, A0A8S7ENK5
    Conserved Domains (1) summary
    PRK05704
    Location:2 → 405
    PRK05704; 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase
Nucleotide Protein
Heading Accession and Version

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