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ddlA D-alanine--D-alanine ligase A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945313, updated on 2-May-2024

Summary

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Gene symbol
ddlA
Gene description
D-alanine--D-alanine ligase A
Primary source
ASAP:ABE-0001309
Locus tag
b0381
See related
ECOCYC:EG10213
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0376
Summary
The subunit structure is not known at this time. [More information is available at EcoCyc: EG10213].
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Genomic context

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Sequence:
NC_000913.3 (399829..400923, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2755 domain-containing inner membrane protein YaiY Neighboring gene DUF2754 domain-containing protein YaiZ Neighboring gene anti-adaptor protein IraP Neighboring gene alkaline phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli. Besong GE, et al. Angew Chem Int Ed Engl, 2005 Oct 7. PMID 16158456
  2. Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B. Park IS, et al. Biochemistry, 1996 Aug 13. PMID 8756703
  3. D-alanine: D-alanine ligase of Escherichia coli. Expression, purification and inhibitory studies on the cloned enzyme. al-Bar OA, et al. Biochem J, 1992 Mar 15. PMID 1554356, Free PMC Article
  4. Existence of two D-alanine:D-alanine ligases in Escherichia coli: cloning and sequencing of the ddlA gene and purification and characterization of the DdlA and DdlB enzymes. Zawadzke LE, et al. Biochemistry, 1991 Feb 12. PMID 1993184
  5. Screen for genes involved in radiation survival of Escherichia coli and construction of a reference database. Sargentini NJ, et al. Mutat Res, 2016 Nov-Dec. PMID 27718375

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables D-alanine-D-alanine ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-alanine-D-alanine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-alanine-D-alanine ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to X-ray IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
D-alanine--D-alanine ligase A
NP_414915.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    399829..400923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414915.1 D-alanine--D-alanine ligase A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414915.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AE43
    Conserved Domains (1) summary
    PRK01966
    Location:1 → 352
    ddl; D-alanine--D-alanine ligase
Nucleotide Protein
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