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sdhC succinate:quinone oxidoreductase, membrane protein SdhC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945316, updated on 2-May-2024

Summary

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Gene symbol
sdhC
Gene description
succinate:quinone oxidoreductase, membrane protein SdhC
Primary source
ASAP:ABE-0002460
Locus tag
b0721
See related
ECOCYC:EG10933
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cybA; cybL; dhsC; ECK0710
Summary
The sdhABCD operon is negatively regulated by ryhB RNA as part of indirect positive regulation by Fur. [More information is available at EcoGene: EG10933]. One of two membrane proteins in the four subunit enzyme. [More information is available at EcoCyc: EG10933].
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Genomic context

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Sequence:
NC_000913.3 (755177..755566)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene citrate synthase Neighboring gene protein YbgV Neighboring gene protein YbgU Neighboring gene succinate:quinone oxidoreductase, membrane protein SdhD Neighboring gene succinate:quinone oxidoreductase, FAD binding protein Neighboring gene succinate:quinone oxidoreductase, iron-sulfur cluster binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chromosomal location of the Escherichia coli cytochrome b556 gene, cybA. Murakami H, et al. Mol Gen Genet, 1984. PMID 6237244
  2. Screening of detergents for solubilization, purification and crystallization of membrane proteins: a case study on succinate:ubiquinone oxidoreductase from Escherichia coli. Shimizu H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Sep 1. PMID 18765923, Free PMC Article
  3. Alternative sites for proton entry from the cytoplasm to the quinone binding site in Escherichia coli succinate dehydrogenase. Cheng VW, et al. Biochemistry, 2008 Sep 2. PMID 18690748
  4. A threonine on the active site loop controls transition state formation in Escherichia coli respiratory complex II. Tomasiak TM, et al. J Biol Chem, 2008 May 30. PMID 18385138, Free PMC Article
  5. Escherichia coli succinate dehydrogenase variant lacking the heme b. Tran QM, et al. Proc Natl Acad Sci U S A, 2007 Nov 13. PMID 17989224, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables succinate dehydrogenase (quinone) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquinone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in aerobic electron transport chain NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within aerobic respiration IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cytochrome complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of succinate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
  
part_of succinate dehydrogenase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
succinate:quinone oxidoreductase, membrane protein SdhC
NP_415249.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    755177..755566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415249.1 succinate:quinone oxidoreductase, membrane protein SdhC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415249.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3MMX8, A0A1X0PPU2, A0A1Y2Y5Q8, A0A5R8TEP5, A0A7U9AVH1, A0A826KU25, A0A8S7CD19, A0A979GVW8, A0A9P2MM69, A0AA35F804, B7MPL5, D3GY60
    Conserved Domains (1) summary
    PRK09487
    Location:1 → 129
    sdhC; succinate dehydrogenase cytochrome b556 subunit
Nucleotide Protein
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