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lptG lipopolysaccharide transport system protein LptG [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945324, updated on 4-Apr-2024

Summary

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Gene symbol
lptG
Gene description
lipopolysaccharide transport system protein LptG
Primary source
ASAP:ABE-0013960
Locus tag
b4262
See related
ECOCYC:G7889
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4255; yjgQ
Summary
YjgQ is an inner membrane protein with six predicted transmembrane domains. [More information is available at EcoCyc: G7889].
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Genomic context

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Sequence:
NC_000913.3 (4487318..4488400)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YtgB Neighboring gene protein YtgA Neighboring gene lipopolysaccharide transport system protein LptF Neighboring gene DUF853 domain-containing protein YjgR Neighboring gene DNA-binding transcriptional dual regulator IdnR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A cluster of residues in the lipopolysaccharide exporter that selects substrate variants for transport to the outer membrane. Bertani BR, et al. Mol Microbiol, 2018 Aug. PMID 29995974, Free PMC Article
  2. Structural basis of lipopolysaccharide extraction by the LptB(2)FGC complex. Li Y, et al. Nature, 2019 Mar. PMID 30894744, Free PMC Article
  3. Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function. Simpson BW, et al. mBio, 2016 Oct 18. PMID 27795402, Free PMC Article
  4. Biochemical characterization of an ABC transporter LptBFGC complex required for the outer membrane sorting of lipopolysaccharides. Narita S, et al. FEBS Lett, 2009 Jul 7. PMID 19500581
  5. Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge. Sherman DJ, et al. Science, 2018 Feb 16. PMID 29449493, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors define residue K34 in LptG as a site within the structural cavity of the Escherichia coli LptB2 FG transporter that interacts electrostatically with phosphates on unmodified lipopolysaccharides.
    Title: A cluster of residues in the lipopolysaccharide exporter that selects substrate variants for transport to the outer membrane.
  2. Taken together, these data identify a specific binding site in LptB for the coupling helices of LptFG that is responsible for coupling of ATP hydrolysis by LptB with LptFG function to achieve lipopolysaccharide extraction.
    Title: Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function.
  3. both LptF and LptG formed a complex with LptB.
    Title: Biochemical characterization of an ABC transporter LptBFGC complex required for the outer membrane sorting of lipopolysaccharides.
  4. YjgP and YjgQ are required for the transport of LPS to the cell surface.
    Title: Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Gram-negative-bacterium-type cell outer membrane assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in lipopolysaccharide transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipopolysaccharide transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipopolysaccharide transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ATP-binding cassette (ABC) transporter complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ATP-binding cassette (ABC) transporter complex IEA
Inferred from Electronic Annotation
more info
  
part_of ATP-binding cassette (ABC) transporter complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of transporter complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lipopolysaccharide transport system protein LptG
NP_418683.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4487318..4488400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418683.4 lipopolysaccharide transport system protein LptG [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418683.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3JRU8, A0A827YIH6, C3SEX2
    Conserved Domains (1) summary
    PRK15071
    Location:4 → 359
    PRK15071; lipopolysaccharide ABC transporter permease; Provisional
Nucleotide Protein
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