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moaE molybdopterin synthase catalytic subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945399, updated on 4-Apr-2024

Summary

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Gene symbol
moaE
Gene description
molybdopterin synthase catalytic subunit
Primary source
ASAP:ABE-0002678
Locus tag
b0785
See related
ECOCYC:EG11598
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
chlA5; ECK0774
Summary
Molybdopterin synthase catalyzes the second segment of the pathway leading to the synthesis of the molybdenum cofactor, molybdopterin guanine dinucleotide, which chelates molybdate and is present in and essential for the activity of all Escherichia coli's molybdenum-containing enzymes. [More information is available at EcoCyc: EG11598].
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Genomic context

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Sequence:
NC_000913.3 (819295..819747)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein MoaB Neighboring gene cyclic pyranopterin monophosphate synthase Neighboring gene molybdopterin synthase sulfur carrier subunit Neighboring gene Bax1-I family protein YbhL Neighboring gene Bax1-I family protein YbhM

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency. Daniels JN, et al. Biochemistry, 2008 Jan 15. PMID 18092812
  2. Thermodynamic analysis of subunit interactions in Escherichia coli molybdopterin synthase. Tong Y, et al. Biochemistry, 2005 Feb 22. PMID 15709772
  3. Structural studies of molybdopterin synthase provide insights into its catalytic mechanism. Rudolph MJ, et al. J Biol Chem, 2003 Apr 18. PMID 12571227
  4. Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis. Wuebbens MM, et al. J Biol Chem, 2003 Apr 18. PMID 12571226
  5. Thiocarboxylation of molybdopterin synthase provides evidence for the mechanism of dithiolene formation in metal-binding pterins. Gutzke G, et al. J Biol Chem, 2001 Sep 28. PMID 11459846

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: The biosynthesis of molybdopterin in Escherichia coli. Purification and characterization of the converting factor.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables molybdopterin synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of MPT synthase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
molybdopterin synthase catalytic subunit
NP_415306.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    819295..819747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415306.1 molybdopterin synthase catalytic subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415306.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7D7PK28, A0A7L5V2W3, A0A8S7YIE0
    Conserved Domains (1) summary
    PRK10678
    Location:1 → 150
    moaE; molybdopterin synthase catalytic subunit MoaE
Nucleotide Protein
Heading Accession and Version

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