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fsaA fructose-6-phosphate aldolase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945449, updated on 23-Nov-2023

Summary

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Gene symbol
fsaA
Gene description
fructose-6-phosphate aldolase 1
Primary source
ASAP:ABE-0002818
Locus tag
b0825
See related
ECOCYC:G6428
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0815; fsa; mipB; ybiZ
Summary
The enzyme is made up of either 10 or 12 subunits. [More information is available at EcoCyc: G6428].
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Genomic context

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Sequence:
NC_000913.3 (863642..864304)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative pyruvate formate lyase Neighboring gene putative pyruvate formate-lyase activating enzyme YbiY Neighboring gene molybdopterin-synthase adenylyltransferase Neighboring gene molybdopterin molybdotransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Opening a Novel Biosynthetic Pathway to Dihydroxyacetone and Glycerol in Escherichia coli Mutants through Expression of a Gene Variant (fsaA(A129S)) for Fructose 6-Phosphate Aldolase. Guitart Font E, et al. Int J Mol Sci, 2020 Dec 17. PMID 33348713, Free PMC Article
  2. Asymmetric self- and cross-aldol reactions of glycolaldehyde catalyzed by D-fructose-6-phosphate aldolase. Garrabou X, et al. Angew Chem Int Ed Engl, 2009. PMID 19554584
  3. D-fructose-6-phosphate aldolase in organic synthesis: cascade chemical-enzymatic preparation of sugar-related polyhydroxylated compounds. Concia AL, et al. Chemistry, 2009. PMID 19222084
  4. D-Fructose-6-phosphate aldolase-catalyzed one-pot synthesis of iminocyclitols. Sugiyama M, et al. J Am Chem Soc, 2007 Nov 28. PMID 17985886
  5. Fructose-6-phosphate aldolase in organic synthesis: preparation of D-fagomine, N-alkylated derivatives, and preliminary biological assays. Castillo JA, et al. Org Lett, 2006 Dec 21. PMID 17165931

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Opening a Novel Biosynthetic Pathway to Dihydroxyacetone and Glycerol in Escherichia coli Mutants through Expression of a Gene Variant (fsaA(A129S)) for Fructose 6-Phosphate Aldolase.
    Title: Opening a Novel Biosynthetic Pathway to Dihydroxyacetone and Glycerol in Escherichia coli Mutants through Expression of a Gene Variant (fsaA(A129S)) for Fructose 6-Phosphate Aldolase.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Fructose-6-phosphate aldolase is a novel class I aldolase from Escherichia coli and is related to a novel group of bacterial transaldolases.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables aldehyde-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables fructose 6-phosphate aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fructose 6-phosphate aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fructose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ketone catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fructose-6-phosphate aldolase 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    863642..864304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415346.4 fructose-6-phosphate aldolase 1 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415346.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8ND32
    Conserved Domains (1) summary
    PRK12653
    Location:1 → 220
    PRK12653; fructose-6-phosphate aldolase; Reviewed
Nucleotide Protein
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Gene LinkOut

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