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dacC D-alanyl-D-alanine carboxypeptidase DacC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945455, updated on 4-Apr-2024

Summary

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Gene symbol
dacC
Gene description
D-alanyl-D-alanine carboxypeptidase DacC
Primary source
ASAP:ABE-0002860
Locus tag
b0839
See related
ECOCYC:EG10203
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0829
Summary
PBP6 is a penicillin-binding protein that is required for proper cell morphology and provides some resistance to penicillin . [More information is available at EcoCyc: EG10203].
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Genomic context

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Sequence:
NC_000913.3 (880727..881929)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene regulator of biofilm formation Neighboring gene aldose sugar dehydrogenase YliI Neighboring gene glutathione S-transferase GstB Neighboring gene DNA-binding transcriptional repressor DeoR Neighboring gene undecaprenyl pyrophosphate phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structures of penicillin-binding protein 6 from Escherichia coli. Chen Y, et al. J Am Chem Soc, 2009 Oct 14. PMID 19807181, Free PMC Article
  2. Synthesis of penicillin-binding protein 6 by stationary-phase Escherichia coli. Buchanan CE, et al. J Bacteriol, 1982 Jul. PMID 7045084, Free PMC Article
  3. Identification of gene products programmed by restriction endonuclease DNA fragments using an E. coli in vitro system. Pratt JM, et al. Nucleic Acids Res, 1981 Sep 25. PMID 6272207, Free PMC Article
  4. Deletion of the penicillin-binding protein 6 gene of Escherichia coli. Broome-Smith JK, et al. J Bacteriol, 1982 Nov. PMID 6215397, Free PMC Article
  5. Possible role of Escherichia coli penicillin-binding protein 6 in stabilization of stationary-phase peptidoglycan. van der Linden MP, et al. J Bacteriol, 1992 Dec. PMID 1447130, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The present report shows that BolA is a transcriptional regulator of the dacA and dacC genes, thus regulating both DD-carboxypeptidases PBP5 and PBP6 and thereby demonstrating the versatility of BolA as a cellular regulator.
    Title: BolA affects cell growth, and binds to the promoters of penicillin-binding proteins 5 and 6 and regulates their expression.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Amino acid sequence homologies between Escherichia coli penicillin-binding protein 5 and class A beta-lactamases.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables penicillin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type D-Ala-D-Ala carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type D-Ala-D-Ala carboxypeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell shape IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-alanyl-D-alanine carboxypeptidase DacC
NP_415360.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    880727..881929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415360.1 D-alanyl-D-alanine carboxypeptidase DacC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415360.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3PU12, A0A1D7PPF7, A0A8E0FSD6, A0AA86WFM8, B1LMD4, D6I7X2, W1EW26
    Conserved Domains (1) summary
    PRK10001
    Location:1 → 400
    PRK10001; serine-type D-Ala-D-Ala carboxypeptidase
Nucleotide Protein
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