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acrD multidrug efflux pump RND permease AcrD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945464, updated on 23-Nov-2023

Summary

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Gene symbol
acrD
Gene description
multidrug efflux pump RND permease AcrD
Primary source
ASAP:ABE-0008136
Locus tag
b2470
See related
ECOCYC:EG10014
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2465; yffA
Summary
acrD mutation confers increased sensitivity to aminoglycosides. acrD is paralogous to acrB. [More information is available at EcoGene: EG10014]. [More information is available at EcoCyc: EG10014].
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Genomic context

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Sequence:
NC_000913.3 (2587595..2590708)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase AegA Neighboring gene sensor histidine kinase NarQ Neighboring gene uncharacterized protein YpfM Neighboring gene putative reductase YffB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Efflux-mediated multiresistance in Gram-negative bacteria. Poole K. Clin Microbiol Infect, 2004 Jan. PMID 14706082
  2. Substrate-dependent dynamics of the multidrug efflux transporter AcrB of Escherichia coli. Yamamoto K, et al. Sci Rep, 2016 Feb 26. PMID 26916090, Free PMC Article
  3. Resistance against antimicrobial peptides is independent of Escherichia coli AcrAB, Pseudomonas aeruginosa MexAB and Staphylococcus aureus NorA efflux pumps. Rieg S, et al. Int J Antimicrob Agents, 2009 Feb. PMID 18945595
  4. Characterisation of cisplatin coordination sites in cellular Escherichia coli DNA-binding proteins by combined biphasic liquid chromatography and ESI tandem mass spectrometry. Will J, et al. J Biol Inorg Chem, 2008 Mar. PMID 18157731
  5. Mammalian steroid hormones are substrates for the major RND- and MFS-type tripartite multidrug efflux pumps of Escherichia coli. Elkins CA, et al. J Bacteriol, 2006 Feb. PMID 16428427, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AcrBA-TolC complex becomes unstable upon the induction of AcrD, which presumably replaces AcrB in the ternary complex. Such instability is suppressed upon the addition of AcrB-specific substrates. The assembly of resistance-nodulation-cell division-type efflux system is a regulated dynamic process that provides bacteria with a highly flexible repertoire of survival strategies to cope with a wide spectrum of antibiotics.
    Title: Substrate-dependent dynamics of the multidrug efflux transporter AcrB of Escherichia coli.
  2. multiple deletion of acrB, acrD, and mdtABC resulted in a significant decrease in enterobactin export and that plasmids carrying the acrAB, acrD, or mdtABC genes restored the decrease in enterobactin export exhibited by the DeltaacrB acrD mdtABC mutant.
    Title: AcrB, AcrD, and MdtABC multidrug efflux systems are involved in enterobactin export in Escherichia coli.
  3. AcrD can also capture aminoglycosides from the periplasm to extrude them into the medium in intact cells, acting as a "periplasmic vacuum cleaner."
    Title: Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables efflux transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables xenobiotic transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bile acid and bile salt transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to toxic substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within xenobiotic transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within xenobiotic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within xenobiotic transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of efflux pump complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of efflux pump complex TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in periplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
multidrug efflux pump RND permease AcrD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2587595..2590708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416965.1 multidrug efflux pump RND permease AcrD [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416965.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M9X022, A0A8S7R0G6
    Conserved Domains (1) summary
    PRK10555
    Location:1 → 1037
    PRK10555; multidrug efflux RND transporter permease AcrD
Nucleotide Protein
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