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serS serine--tRNA ligase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945506, updated on 6-Oct-2023

Summary

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Gene symbol
serS
Gene description
serine--tRNA ligase
Primary source
ASAP:ABE-0003038
Locus tag
b0893
See related
ECOCYC:EG10947
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0884
Summary
Seryl-tRNA synthetase (SerRS) is a member of the family of aminoacyl-tRNA synthetases, which interpret the genetic code by covalently linking amino acids to their specific tRNA molecules. [More information is available at EcoCyc: EG10947].
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Genomic context

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Sequence:
NC_000913.3 (939428..940720)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene outer membrane lipoprotein carrier protein Neighboring gene replication-associated recombination protein A Neighboring gene dimethyl sulfoxide reductase subunit A Neighboring gene dimethyl sulfoxide reductase subunit B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hydrolysis of non-cognate aminoacyl-adenylates by a class II aminoacyl-tRNA synthetase lacking an editing domain. Gruic-Sovulj I, et al. FEBS Lett, 2007 Oct 30. PMID 17931630
  2. Selective inhibition of divergent seryl-tRNA synthetases by serine analogues. Ahel D, et al. FEBS Lett, 2005 Aug 15. PMID 16054140
  3. tRNA recognition and evolution of determinants in seryl-tRNA synthesis. Lenhard B, et al. Nucleic Acids Res, 1999 Feb 1. PMID 9889265, Free PMC Article
  4. Protein dissection of the antiparallel coiled coil from Escherichia coli seryl tRNA synthetase. Oakley MG, et al. Biochemistry, 1997 Mar 4. PMID 9054560
  5. Variant minihelix RNAs reveal sequence-specific recognition of the helical tRNA(Ser) acceptor stem by E.coli seryl-tRNA synthetase. Saks ME, et al. EMBO J, 1996 Jun 3. PMID 8654382, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within selenocysteine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in selenocysteine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within seryl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in seryl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in seryl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine--tRNA ligase
NP_415413.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    939428..940720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415413.1 serine--tRNA ligase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415413.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377E7J2, A0A5B9AND2
    Conserved Domains (1) summary
    PRK05431
    Location:1 → 430
    PRK05431; seryl-tRNA synthetase; Provisional
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials