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dmsA dimethyl sulfoxide reductase subunit A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945508, updated on 4-Feb-2024

Summary

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Gene symbol
dmsA
Gene description
dimethyl sulfoxide reductase subunit A
Primary source
ASAP:ABE-0003044
Locus tag
b0894
See related
ECOCYC:EG10232
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0885
Summary
Verified Tat substrate: [More information is available at EcoGene: EG10232]. This subunit contains the active site and the molybdenum cofactor . [More information is available at EcoCyc: EG10232].
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Genomic context

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Sequence:
NC_000913.3 (940959..943403)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene replication-associated recombination protein A Neighboring gene serine--tRNA ligase Neighboring gene dimethyl sulfoxide reductase subunit B Neighboring gene dimethyl sulfoxide reductase subunit C

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple roles for the twin arginine leader sequence of dimethyl sulfoxide reductase of Escherichia coli. Sambasivarao D, et al. J Biol Chem, 2000 Jul 21. PMID 10801884
  2. Molecular cloning and expression of the Escherichia coli dimethyl sulfoxide reductase operon. Bilous PT, et al. J Bacteriol, 1988 Apr. PMID 2832366, Free PMC Article
  3. The hydrophobic region of the DmsA twin-arginine leader peptide determines specificity with chaperone DmsD. Winstone TM, et al. Biochemistry, 2013 Oct 29. PMID 24093457, Free PMC Article
  4. Correct assembly of iron-sulfur cluster FS0 into Escherichia coli dimethyl sulfoxide reductase (DmsABC) is a prerequisite for molybdenum cofactor insertion. Tang H, et al. J Biol Chem, 2011 Apr 29. PMID 21357619, Free PMC Article
  5. Identification of residues in DmsD for twin-arginine leader peptide binding, defined through random and bioinformatics-directed mutagenesis. Chan CS, et al. Biochemistry, 2008 Mar 4. PMID 18247574

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that a portion of the hydrophobic region of the DmsA leader peptide determines the specificity of binding and may produce helical properties upon binding to chaperone protein DmsD (twin-arginine leader-binding protein).
    Title: The hydrophobic region of the DmsA twin-arginine leader peptide determines specificity with chaperone DmsD.
  2. established an additional role for the cluster in directing molybdenum cofactor assembly during enzyme maturation
    Title: Correct assembly of iron-sulfur cluster FS0 into Escherichia coli dimethyl sulfoxide reductase (DmsABC) is a prerequisite for molybdenum cofactor insertion.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Nucleotide sequence of the dmsABC operon encoding the anaerobic dimethylsulphoxide reductase of Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables dimethyl sulfoxide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables electron transfer activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdenum ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molybdenum ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin cofactor binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaerobic electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within anaerobic respiration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in dimethyl sulfoxide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of dimethyl sulfoxide reductase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of dimethyl sulfoxide reductase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dimethyl sulfoxide reductase subunit A
NP_415414.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    940959..943403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415414.4 dimethyl sulfoxide reductase subunit A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415414.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M9WS45, A0A827Y3E7
    Conserved Domains (1) summary
    PRK14990
    Location:1 → 814
    PRK14990; anaerobic dimethyl sulfoxide reductase subunit A; Provisional
Nucleotide Protein
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Gene LinkOut

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