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lpxK tetraacyldisaccharide 4'-kinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945526, updated on 2-May-2024

Summary

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Gene symbol
lpxK
Gene description
tetraacyldisaccharide 4'-kinase
Primary source
ASAP:ABE-0003115
Locus tag
b0915
See related
ECOCYC:EG11409
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0906; ycaH
Summary
Tetraacyldisaccharide 4'-kinase (LpxK) catalyzes the sixth step in lipid A biosynthesis. [More information is available at EcoCyc: EG11409].
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Genomic context

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Sequence:
NC_000913.3 (968366..969352)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene integration host factor subunit beta Neighboring gene metallo-beta-lactamase superfamily inner membrane protein YcaI Neighboring gene ATP-binding lipopolysaccharide transport protein Neighboring gene interstrand DNA crosslink repair glycosylase Neighboring gene PF03966 family protein YcaR Neighboring gene 3-deoxy-manno-octulosonate cytidylyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of the gene encoding the Escherichia coli lipid A 4'-kinase. Facile phosphorylation of endotoxin analogs with recombinant LpxK. Garrett TA, et al. J Biol Chem, 1997 Aug 29. PMID 9268317
  2. The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4'-phosphate of lipid A. Ray BL, et al. J Biol Chem, 1987 Jan 25. PMID 3027079
  3. Lipid A 4'-kinase from Escherichia coli: enzyme assay and preparation of 4'-32P-labeled probes of high specific radioactivity. Hampton RY, et al. Methods Enzymol, 1992. PMID 1323052
  4. The essential Escherichia coli msbA gene, a multicopy suppressor of null mutations in the htrB gene, is related to the universally conserved family of ATP-dependent translocators. Karow M, et al. Mol Microbiol, 1993 Jan. PMID 8094880
  5. Lipid A modification systems in gram-negative bacteria. Raetz CR, et al. Annu Rev Biochem, 2007. PMID 17362200, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables tetraacyldisaccharide 4'-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tetraacyldisaccharide 4'-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tetraacyldisaccharide 4'-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables tetraacyldisaccharide 4'-kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid A biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid A biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipopolysaccharide core region biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tetraacyldisaccharide 4'-kinase
NP_415435.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    968366..969352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415435.1 tetraacyldisaccharide 4'-kinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415435.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3R0MX50
    Conserved Domains (1) summary
    PRK00652
    Location:1 → 321
    lpxK; tetraacyldisaccharide 4'-kinase; Reviewed
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases