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serC phosphoserine/phosphohydroxythreonine aminotransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945527, updated on 11-Apr-2024

Summary

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Gene symbol
serC
Gene description
phosphoserine/phosphohydroxythreonine aminotransferase
Primary source
ASAP:ABE-0003093
Locus tag
b0907
See related
ECOCYC:EG10946
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0898; pdxC; pdxF
Summary
The serC-encoded enzyme, phosphoserine/phosphohydroxythreonine aminotransferase, functions in the biosythesis of both serine and pyridoxine, by using different substrates . [More information is available at EcoCyc: EG10946].
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Genomic context

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Sequence:
NC_000913.3 (957653..958741)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ribosomal protein S12 methylthiotransferase accessory factor YcaO Neighboring gene DUF421 domain-containing protein YcaP Neighboring gene 3-phosphoshikimate 1-carboxyvinyltransferase Neighboring gene periplasmic protease YcaL

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. serC is involved in vitamin B6 biosynthesis in Escherichia coli but not in Bacillus subtilis. Sakai A, et al. J Biosci Bioeng, 2002. PMID 16233211
  2. Crystal structure of phosphoserine aminotransferase from Escherichia coli at 2.3 A resolution: comparison of the unligated enzyme and a complex with alpha-methyl-l-glutamate. Hester G, et al. J Mol Biol, 1999 Feb 26. PMID 10024454
  3. 4-O-phosphoryl-L-threonine, a substrate of the pdxC(serC) gene product involved in vitamin B6 biosynthesis. Drewke C, et al. FEBS Lett, 1996 Jul 22. PMID 8706854
  4. Close linkage of the genes serC (for phosphohydroxy pyruvate transaminase) and serS (for seryl-transfer ribonucleic acid synthetase) in Escherichia coli K-12. Clarke SJ, et al. J Bacteriol, 1973 Mar. PMID 4570768, Free PMC Article
  5. Characterization of pyridoxine auxotrophs of Escherichia coli: serine and pdxF mutants. Dempsey WB, et al. J Bacteriol, 1970 Nov. PMID 4321330, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: '98 Escherichia coli SWISS-2DPAGE database update.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-serine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-serine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-serine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-serine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-serine metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in pyridoxal phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyridoxine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphoserine/phosphohydroxythreonine aminotransferase
NP_415427.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    957653..958741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415427.1 phosphoserine/phosphohydroxythreonine aminotransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415427.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AB75
    Conserved Domains (1) summary
    PRK05355
    Location:1 → 362
    PRK05355; 3-phosphoserine/phosphohydroxythreonine transaminase
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials