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ddpX D-alanyl-D-alanine dipeptidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945532, updated on 4-Feb-2024

Summary

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Gene symbol
ddpX
Gene description
D-alanyl-D-alanine dipeptidase
Primary source
ASAP:ABE-0004960
Locus tag
b1488
See related
ECOCYC:G6782
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1482; vanX; yddT
Summary
RpoS regulon. [More information is available at EcoGene: EG13791]. VanX is a D-Ala-D-Ala dipeptidase, which catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide required for wild-type peptidoglycan biosynthesis . [More information is available at EcoCyc: G6782].
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Genomic context

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Sequence:
NC_000913.3 (1562495..1563076, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative D,D-dipeptide ABC transporter membrane subunit DdpC Neighboring gene putative D,D-dipeptide ABC transporter membrane subunit DdpB Neighboring gene putative D,D-dipeptide ABC transporter periplasmic binding protein Neighboring gene oxygen-sensing c-di-GMP phosphodiesterase DosP Neighboring gene diguanylate cyclase DosC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. VanX, a bacterial D-alanyl-D-alanine dipeptidase: resistance, immunity, or survival function? Lessard IA, et al. Proc Natl Acad Sci U S A, 1999 Sep 28. PMID 10500118, Free PMC Article
  2. Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function. Lessard IA, et al. Chem Biol, 1998 Sep. PMID 9751644
  3. Nitrogen regulatory protein C-controlled genes of Escherichia coli: scavenging as a defense against nitrogen limitation. Zimmer DP, et al. Proc Natl Acad Sci U S A, 2000 Dec 19. PMID 11121068, Free PMC Article
  4. MEROPS: the peptidase database. Rawlings ND, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381862, Free PMC Article
  5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables dipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc D-Ala-D-Ala carboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to starvation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-alanyl-D-alanine dipeptidase
NP_416005.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1562495..1563076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416005.1 D-alanyl-D-alanine dipeptidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416005.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1MKC8, A0A3L9I2V3, A0A6M9WVR4
    Conserved Domains (1) summary
    PRK10178
    Location:1 → 182
    PRK10178; D-alanyl-D-alanine dipeptidase; Provisional
Nucleotide Protein
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