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cmk cytidylate kinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945535, updated on 2-May-2024

Summary

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Gene symbol
cmk
Gene description
cytidylate kinase
Primary source
ASAP:ABE-0003101
Locus tag
b0910
See related
ECOCYC:EG11265
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0901; mssA; ycaF; ycaG
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Genomic context

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Sequence:
NC_000913.3 (961201..961884)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-phosphoshikimate 1-carboxyvinyltransferase Neighboring gene periplasmic protease YcaL Neighboring gene 30S ribosomal subunit protein S1 Neighboring gene integration host factor subunit beta

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multifaceted impact of a nucleoside monophosphate kinase on 5'-end-dependent mRNA degradation in bacteria. Hui MP, et al. Nucleic Acids Res, 2021 Nov 8. PMID 34643703, Free PMC Article
  2. Mimicking direct protein-protein and solvent-mediated interactions in the CDP-methylerythritol kinase homodimer: a pharmacophore-directed virtual screening approach. Giménez-Oya V, et al. J Mol Model, 2009 Aug. PMID 19198899
  3. Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase. Ofiteru A, et al. FEBS J, 2007 Jul. PMID 17542990
  4. Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme. Bertrand T, et al. J Mol Biol, 2002 Feb 1. PMID 11827479
  5. Substrate-induced fit of the ATP binding site of cytidine monophosphate kinase from Escherichia coli: time-resolved fluorescence of 3'-anthraniloyl-2'-deoxy-ADP and molecular modeling. Li de La Sierra IM, et al. Biochemistry, 2000 Dec 26. PMID 11123913

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Multifaceted impact of a nucleoside monophosphate kinase on 5'-end-dependent mRNA degradation in bacteria.
    Title: Multifaceted impact of a nucleoside monophosphate kinase on 5'-end-dependent mRNA degradation in bacteria.
  2. Data show a molecular dynamics simulation on the CMK dimer complex, and protein-protein interactions.
    Title: Mimicking direct protein-protein and solvent-mediated interactions in the CDP-methylerythritol kinase homodimer: a pharmacophore-directed virtual screening approach.
  3. analysis of of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase
    Title: Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CMP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cytidylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytidylate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytidylate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables dCMP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanosine tetraphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleobase-containing small molecule interconversion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleobase-containing small molecule interconversion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to X-ray IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytidylate kinase
NP_415430.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    961201..961884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415430.1 cytidylate kinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415430.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MUU5, A0A827QHU3
    Conserved Domains (1) summary
    PRK00023
    Location:2 → 225
    cmk; (d)CMP kinase
Nucleotide Protein
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