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pyrD dihydroorotate dehydrogenase, type 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945556, updated on 27-Nov-2023

Summary

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Gene symbol
pyrD
Gene description
dihydroorotate dehydrogenase, type 2
Primary source
ASAP:ABE-0003201
Locus tag
b0945
See related
ECOCYC:EG10807
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0936
Summary
The enzyme is a membrane-bound flavoprotein. [More information is available at EcoCyc: EG10807].
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Genomic context

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Sequence:
NC_000913.3 (1004768..1005778)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative fimbrial protein YcbU Neighboring gene putative fimbrial protein YcbV Neighboring gene putative fimbrial chaperone YcbF Neighboring gene cell division protein ZapC Neighboring gene 6-N-hydroxylaminopurine resistance protein Neighboring gene fused 23S rRNA m(2)G2445 methyltransferase and 23S rRNA m(7)G2069 methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of the proton relay network in the class 2 dihydroorotate dehydrogenase from Escherichia coli. Kow RL, et al. Biochemistry, 2009 Oct 20. PMID 19694481, Free PMC Article
  2. Roles in binding and chemistry for conserved active site residues in the class 2 dihydroorotate dehydrogenase from Escherichia coli. Fagan RL, et al. Biochemistry, 2009 Aug 4. PMID 19530672, Free PMC Article
  3. Defects in vesicle core induced by escherichia coli dihydroorotate dehydrogenase. Couto SG, et al. Biophys J, 2008 Mar 1. PMID 17993483, Free PMC Article
  4. Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases. Fagan RL, et al. Biochemistry, 2006 Dec 19. PMID 17154530
  5. Multiple states of the Tyr318Leu mutant of dihydroorotate dehydrogenase revealed by single-molecule kinetics. Shi J, et al. J Am Chem Soc, 2004 Jun 9. PMID 15174861

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. New Insights into the Interaction of Class II Dihydroorotate Dehydrogenases with Ubiquinone in Lipid Bilayers as a Function of Lipid Composition.
    Title: New Insights into the Interaction of Class II Dihydroorotate Dehydrogenases with Ubiquinone in Lipid Bilayers as a Function of Lipid Composition.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Nucleotide sequence of the pyrD gene of Escherichia coli and characterization of the flavoprotein dihydroorotate dehydrogenase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FMN binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydroorotate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydroorotate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydroorotate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydroorotate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within 'de novo' pyrimidine nucleobase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine ribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dihydroorotate dehydrogenase, type 2
NP_415465.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1004768..1005778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415465.1 dihydroorotate dehydrogenase, type 2 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415465.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A827Y4C7
    Conserved Domains (1) summary
    PRK05286
    Location:1 → 336
    PRK05286; quinone-dependent dihydroorotate dehydrogenase
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials