ndk nucleoside diphosphate kinase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Gene symbol: ndk
Gene description: nucleoside diphosphate kinase
Primary source: ASAP:ABE-0008291
Locus tag: b2518
See related: ECOCYC:EG10650
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2514
Summary: Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG10650]. Nucleoside diphosphate kinase catalyzes the reaction in which the terminal phosphate of a nucleoside-triphosphate is transferred to a nucleoside-diphosphate. [More information is available at EcoCyc: EG10650].
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NC_000913.3 Genomic Context describing neighboring genes

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Mutation rates and dNTP pool changes in ndk mutants
Title: Mutational consequences of dNTP pool imbalances in E. coli.
SOS induction of Y family polymerases is necessary to prevent mutagenesis in an ndk mutant background.
Title: Escherichia coli nucleoside diphosphate kinase mutants depend on translesion DNA synthesis to prevent mutagenesis.
N-terminus verified by Edman degradation on mature peptide
Title: Nucleoside diphosphokinase: a functional link between intermediary metabolism and nucleic acid synthesis.
In contrast to the robust uracil excision activity reported for E. coli NDK, the Mycobacterium tuberculosis NDK preparation exhibited very poor excision of uracil from DNA.
Title: Mycobacterium tuberculosis and Escherichia coli nucleoside diphosphate kinases lack multifunctional activities to process uracil containing DNA.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine nucleotide metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_417013.1

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