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leuD 3-isopropylmalate dehydratase subunit LeuD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945642, updated on 11-Apr-2024

Summary

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Gene symbol
leuD
Gene description
3-isopropylmalate dehydratase subunit LeuD
Primary source
ASAP:ABE-0000259
Locus tag
b0071
See related
ECOCYC:EG11575
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0073
Summary
Isopropylmalate isomerase catalyzes the second step in leucine biosynthesis, converting 2-isopropylmalate to 3-isopropylmalate. [More information is available at EcoCyc: EG11575].
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Genomic context

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Sequence:
NC_000913.3 (78848..79453, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene PtsG glucose transporter inhibitor Neighboring gene sugar exporter SetA Neighboring gene 3-isopropylmalate dehydratase subunit LeuC Neighboring gene 3-isopropylmalate dehydrogenase Neighboring gene 2-isopropylmalate synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Micromolar intracellular hydrogen peroxide disrupts metabolism by damaging iron-sulfur enzymes. Jang S, et al. J Biol Chem, 2007 Jan 12. PMID 17102132, Free PMC Article
  2. Wild-type isopropylmalate isomerase in Salmonella typhimurium is composed of two different subunits. Fultz PN, et al. J Bacteriol, 1981 Oct. PMID 7026530, Free PMC Article
  3. Salmonella typhimurium newD and Escherichia coli leuC genes code for a functional isopropylmalate isomerase in Salmonella typhimurium-Escherichia coli hybrids. Fultz PN, et al. J Bacteriol, 1979 Mar. PMID 374346, Free PMC Article
  4. Genetic analysis of the leucine region in Escherichia coli B-r: gene-enzyme assignments. Yang HL, et al. J Bacteriol, 1974 Jan. PMID 4587614, Free PMC Article
  5. Isolation and characterization of lambda pleu bacteriophages. Davis MG, et al. J Bacteriol, 1977 Feb. PMID 320178, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Protein identification with N and C-terminal sequence tags in proteome projects.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-isopropylmalate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-leucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-leucine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-leucine biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 3-isopropylmalate dehydratase complex IEA
Inferred from Electronic Annotation
more info
  
part_of 3-isopropylmalate dehydratase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of 3-isopropylmalate dehydratase complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-isopropylmalate dehydratase subunit LeuD
NP_414613.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    78848..79453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414613.1 3-isopropylmalate dehydratase subunit LeuD [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414613.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ALE3
    Conserved Domains (1) summary
    PRK01641
    Location:3 → 200
    leuD; 3-isopropylmalate dehydratase small subunit
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases