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fabG 3-oxoacyl-[acyl-carrier-protein] reductase FabG [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945645, updated on 4-Apr-2024

Summary

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Gene symbol
fabG
Gene description
3-oxoacyl-[acyl-carrier-protein] reductase FabG
Primary source
ASAP:ABE-0003700
Locus tag
b1093
See related
ECOCYC:EG11318
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1079
Summary
FabG converts ethyl 4-chloroacetoacetate (ECAA) to ethyl ( S)-4-chloro-3-hydroxybutanoate (ECHB) in vitro. [More information is available at EcoGene: EG11318]. Cotranscribed with acpP. [More information is available at EcoCyc: EG11318].
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Genomic context

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Sequence:
NC_000913.3 (1150670..1151404)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-oxoacyl-[acyl carrier protein] synthase 3 Neighboring gene [acyl-carrier-protein] S-malonyltransferase Neighboring gene acyl carrier protein Neighboring gene 3-oxoacyl-[acyl carrier protein] synthase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Escherichia coli FabG 3-ketoacyl-ACP reductase proteins lacking the assigned catalytic triad residues are active enzymes. Hu Z, et al. J Biol Chem, 2021 Jan-Jun. PMID 33545175, Free PMC Article
  2. Novel inhibitors of beta-ketoacyl-ACP reductase from Escherichia coli. Kristan K, et al. Chem Biol Interact, 2009 Mar 16. PMID 18977209
  3. FabG mediates polyhydroxyalkanoate production from both related and nonrelated carbon sources in recombinant Escherichia coli LS5218. Nomura CT, et al. Biotechnol Prog, 2008 Mar-Apr. PMID 18215055
  4. Inhibitory activity of chlorogenic acid on enzymes involved in the fatty acid synthesis in animals and bacteria. Li BH, et al. IUBMB Life, 2006 Jan. PMID 16540431
  5. Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG. Price AC, et al. Structure, 2004 Mar. PMID 15016358

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Escherichia coli FabG 3-ketoacyl-ACP reductase proteins lacking the assigned catalytic triad residues are active enzymes.
    Title: Escherichia coli FabG 3-ketoacyl-ACP reductase proteins lacking the assigned catalytic triad residues are active enzymes.
  2. FabG1 activity can be replaced by the corresponding enzyme from the closely related species Mycobacterium smegmatis but not by the enzyme from Escherichia coli
    Title: Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but not Escherichia coli fabG.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within biotin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-oxoacyl-[acyl-carrier-protein] reductase FabG
NP_415611.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1150670..1151404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415611.1 3-oxoacyl-[acyl-carrier-protein] reductase FabG [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415611.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AAN5
    Conserved Domains (1) summary
    PRK05557
    Location:1 → 244
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
Nucleotide Protein
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