U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

dhaK dihydroxyacetone kinase subunit K [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945747, updated on 2-May-2024

Summary

Go to the top of the page Help
Gene symbol
dhaK
Gene description
dihydroxyacetone kinase subunit K
Primary source
ASAP:ABE-0004029
Locus tag
b1200
See related
ECOCYC:G6627
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dhaK1; ECK1188; ycgT
Summary
DhaK is similar to N-terminal half of single protein DHA kinases. [More information is available at EcoGene: EG13901]. The K subunit is similar to the N-terminal half of ATP-dependent dihydroxyacetone kinase of Citrobacter freundii and eukaryotes. [More information is available at EcoCyc: G6627].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (1249768..1250838, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene dihydroxyacetone kinase subunit M Neighboring gene dihydroxyacetone kinase subunit L Neighboring gene DNA-binding transcriptional dual regulator DhaR Neighboring gene putative autotransporter adhesin YcgV

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase. Shi R, et al. Proc Natl Acad Sci U S A, 2011 Jan 25. PMID 21209328, Free PMC Article
  2. Heterodimeric dihydroxyacetone kinase from a ptsI mutant of Escherichia coli. Beutler R, et al. Microbiology (Reading), 2001 Feb. PMID 11158340
  3. Coiled-coil helix rotation selects repressing or activating state of transcriptional regulator DhaR. Shi R, et al. Structure, 2014 Mar 4. PMID 24440518
  4. From ATP as substrate to ADP as coenzyme: functional evolution of the nucleotide binding subunit of dihydroxyacetone kinases. Bächler C, et al. J Biol Chem, 2005 May 6. PMID 15753087
  5. Phosphoenolpyruvate- and ATP-dependent dihydroxyacetone kinases: covalent substrate-binding and kinetic mechanism. Garcia-Alles LF, et al. Biochemistry, 2004 Oct 19. PMID 15476397

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the structure of dihydroxyacetone kinase complex DhaK undergoes significant conformational changes to accommodate binding of DhaL.
    Title: Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glycerone kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerone kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoenolpyruvate-glycerone phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoenolpyruvate-glycerone phosphotransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphoenolpyruvate-glycerone phosphotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in carbohydrate phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycerol to glycerone phosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ketone catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monosaccharide catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyruvate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
dihydroxyacetone kinase subunit K
NP_415718.6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1249768..1250838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415718.6 dihydroxyacetone kinase subunit K [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415718.6

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377DTD8
    Conserved Domains (1) summary
    PRK11468
    Location:1 → 356
    PRK11468; dihydroxyacetone kinase subunit DhaK; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.