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dhaL dihydroxyacetone kinase subunit L [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945748, updated on 2-May-2024

Summary

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Gene symbol
dhaL
Gene description
dihydroxyacetone kinase subunit L
Primary source
ASAP:ABE-0004026
Locus tag
b1199
See related
ECOCYC:G6626
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dhaK2; ECK1187; ycgS; ysgS
Summary
DhaL is similar to C-terminal half of single protein DHA kinases. [More information is available at EcoGene: EG13900]. The L subunit is similar to the C-terminal half of ATP-dependent dihydroxyacetone kinases of eukaryotes and other bacteria. [More information is available at EcoCyc: G6626].
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Genomic context

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Sequence:
NC_000913.3 (1249125..1249757, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene periplasmic trehalase Neighboring gene dihydroxyacetone kinase subunit M Neighboring gene dihydroxyacetone kinase subunit K Neighboring gene DNA-binding transcriptional dual regulator DhaR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of the nucleotide-binding subunit DhaL of the Escherichia coli dihydroxyacetone kinase. Oberholzer AE, et al. J Mol Biol, 2006 Jun 9. PMID 16647083
  2. Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase. Shi R, et al. Proc Natl Acad Sci U S A, 2011 Jan 25. PMID 21209328, Free PMC Article
  3. Heterodimeric dihydroxyacetone kinase from a ptsI mutant of Escherichia coli. Beutler R, et al. Microbiology (Reading), 2001 Feb. PMID 11158340
  4. Coiled-coil helix rotation selects repressing or activating state of transcriptional regulator DhaR. Shi R, et al. Structure, 2014 Mar 4. PMID 24440518
  5. From ATP as substrate to ADP as coenzyme: functional evolution of the nucleotide binding subunit of dihydroxyacetone kinases. Bächler C, et al. J Biol Chem, 2005 May 6. PMID 15753087

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the structure of dihydroxyacetone kinase complex DhaK undergoes significant conformational changes to accommodate binding of DhaL.
    Title: Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerone kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoenolpyruvate-glycerone phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoenolpyruvate-glycerone phosphotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyruvate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
dihydroxyacetone kinase subunit L
NP_415717.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1249125..1249757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415717.1 dihydroxyacetone kinase subunit L [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415717.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8R0H0
    Conserved Domains (1) summary
    PRK10005
    Location:1 → 210
    PRK10005; dihydroxyacetone kinase ADP-binding subunit DhaL
Nucleotide Protein
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