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dadA D-amino acid dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945752, updated on 4-Apr-2024

Summary

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Gene symbol
dadA
Gene description
D-amino acid dehydrogenase
Primary source
ASAP:ABE-0003995
Locus tag
b1189
See related
ECOCYC:EG11407
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dadR; ECK1177
Summary
dadR is the name that was assigned to cis-acting regulatory mutations in the dadA promoter region. [More information is available at EcoGene: EG11407]. The enzyme is composed of two non-identical subunits, the gene dadA codes for the smaller unit and an unidentified gene for the larger. [More information is available at EcoCyc: EG11407].
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Genomic context

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Sequence:
NC_000913.3 (1237571..1238869)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator FadR Neighboring gene PF04293 family protein YcgB Neighboring gene alanine racemase 2 Neighboring gene protein YmgM Neighboring gene putative K(+):H(+) antiporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic studies of D-alanine-dehydrogenase-less mutants of Escherichia coli K12. Franklin FC, et al. Genet Res, 1981 Oct. PMID 7035293
  2. Solubilisation of D-amino acid dehydrogenase of Escherichia coli K12 and its re-binding to envelope preparations. Jones H, et al. Biochimie, 1983 Mar. PMID 6133564
  3. Effects of solubilisation on some properties of the membrane-bound respiratory enzyme D-amino acid dehydrogenase of Escherichia coli. Jones H, et al. FEBS Lett, 1983 Jan 24. PMID 6131836
  4. Regulation of expression of the dadA gene encoding D-amino acid dehydrogenase in Escherichia coli: analysis of dadA-lac fusions and direction of dadA transcription. Wild J, et al. Mol Gen Genet, 1982. PMID 6126797
  5. Purification and properties of D-amino acid dehydrogenase, an inducible membrane-bound iron-sulfur flavoenzyme from Escherichia coli B. Olsiewski PJ, et al. J Biol Chem, 1980 May 25. PMID 6102989

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables D-amino-acid dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-amino-acid dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-amino-acid dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-alanine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in D-alanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in D-alanine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in D-amino acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-alanine oxidation to pyruvate via D-alanine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-amino acid dehydrogenase
NP_415707.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1237571..1238869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415707.1 D-amino acid dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415707.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7A6XQY3, A0A7H9QQJ2, A0A8S7JDV1
    Conserved Domains (1) summary
    PRK00711
    Location:1 → 415
    PRK00711; D-amino acid dehydrogenase
Nucleotide Protein
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