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dadX alanine racemase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945754, updated on 2-May-2024

Summary

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Gene symbol
dadX
Gene description
alanine racemase 2
Primary source
ASAP:ABE-0003997
Locus tag
b1190
See related
ECOCYC:EG11408
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
alnA; alnB; dadB; ECK1178
Summary
Alanine racemase 2 (DadX) catalyzes the interconversion of D- and L-alanine. [More information is available at EcoCyc: EG11408].
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Genomic context

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Sequence:
NC_000913.3 (1238879..1239949)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF04293 family protein YcgB Neighboring gene D-amino acid dehydrogenase Neighboring gene protein YmgM Neighboring gene putative K(+):H(+) antiporter Neighboring gene murein tetrapeptide carboxypeptidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism of D-cycloserine action: alanine racemase from Escherichia coli W. Lambert MP, et al. J Bacteriol, 1972 Jun. PMID 4555420, Free PMC Article
  2. Studies on Escherichia coli enzymes involved in the synthesis of uridine diphosphate-N-acetyl-muramyl-pentapeptide. Lugtenberg EJ. J Bacteriol, 1972 Apr. PMID 4552992, Free PMC Article
  3. Factors affecting the level of alanine racemase in Escherichia coli. Lambert MP, et al. J Bacteriol, 1972 Mar. PMID 4551748, Free PMC Article
  4. D-alanine oxidase from Escherichia coli: participation in the oxidation of L-alanine. Raunio RP, et al. J Bacteriol, 1973 Aug. PMID 4146873, Free PMC Article
  5. Peptidoglycan biosynthesis in Escherichia coli: variations in the metabolism of alanine and D-alanyl-D-alanine. de Roubin MR, et al. J Gen Microbiol, 1992 Aug. PMID 1527514

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables alanine racemase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alanine racemase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alanine racemase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-alanine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-alanine oxidation to pyruvate via D-alanine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in alanine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alanine racemase 2
NP_415708.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1238879..1239949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415708.1 alanine racemase 2 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415708.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7D7KEW7
    Conserved Domains (1) summary
    PRK03646
    Location:2 → 356
    dadX; catabolic alanine racemase
Nucleotide Protein
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