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ldcA murein tetrapeptide carboxypeptidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945756, updated on 6-Oct-2023

Summary

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Gene symbol
ldcA
Gene description
murein tetrapeptide carboxypeptidase
Primary source
ASAP:ABE-0004002
Locus tag
b1192
See related
ECOCYC:G6621
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1180; ycgQ
Summary
LdcA mutants can lyse in stationary phase (Templin, 1999; Herve, 2007). [More information is available at EcoGene: EG13898]. LdcA is an L,D-carboxypeptidase that has an essential function in murein (peptidoglycan) recycling/turnover . [More information is available at EcoCyc: G6621].
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Genomic context

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Sequence:
NC_000913.3 (1242166..1243080, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene alanine racemase 2 Neighboring gene protein YmgM Neighboring gene putative K(+):H(+) antiporter Neighboring gene lytic murein transglycosylase E Neighboring gene flagellar brake protein YcgR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Horizontal-Acquisition of a Promiscuous Peptidoglycan-Recycling Enzyme Enables Aphids To Influence Symbiont Cell Wall Metabolism. Smith TE, et al. mBio, 2021 Dec 21. PMID 34933456, Free PMC Article
  2. The crystal structure and oligomeric form of Escherichia colil,d-carboxypeptidase A. Meyer K, et al. Biochem Biophys Res Commun, 2018 May 15. PMID 29601819
  3. Identification of a dithiazoline inhibitor of Escherichia coli L,D-carboxypeptidase A. Baum EZ, et al. Antimicrob Agents Chemother, 2005 Nov. PMID 16251288, Free PMC Article
  4. Substrate specificity of Escherichia coli LD-carboxypeptidase on biosynthetically modified muropeptides. Leguina JI, et al. FEBS Lett, 1994 Feb 21. PMID 8112463
  5. LD-carboxypeptidase activity in Escherichia coli. II. Isolation, purification and characterization of the enzyme from E. coli K 12. Metz R, et al. Arch Microbiol, 1986 Mar. PMID 3521530

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables muramoyltetrapeptide carboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables muramoyltetrapeptide carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidoglycan cross-bridge peptide endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan turnover IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidoglycan turnover IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan turnover IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
murein tetrapeptide carboxypeptidase
NP_415710.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1242166..1243080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415710.1 murein tetrapeptide carboxypeptidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415710.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6D0I975
    Conserved Domains (1) summary
    PRK11253
    Location:1 → 304
    ldcA; L,D-carboxypeptidase A; Provisional
Nucleotide Protein
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