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narH nitrate reductase A subunit beta [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945780, updated on 4-Feb-2024

Summary

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Gene symbol
narH
Gene description
nitrate reductase A subunit beta
Primary source
ASAP:ABE-0004121
Locus tag
b1225
See related
ECOCYC:EG10639
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
chlC; ECK1219
Summary
Induced by anaerobiosis plus nitrate. [More information is available at EcoGene: EG10639]. The subunit is the electron transfer subunit containing the iron-sulfur clusters, one [3Fe-4S] cluster and three [4Fe-4S] clusters . [More information is available at EcoCyc: EG10639].
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Genomic context

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Sequence:
NC_000913.3 (1283604..1285142)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator NarL Neighboring gene sensor histidine kinase NarX Neighboring gene nitrate:nitrite antiporter NarK Neighboring gene ncRNA Neighboring gene nitrate reductase A subunit alpha Neighboring gene nitrate reductase 1 molybdenum cofactor assembly chaperone Neighboring gene nitrate reductase A subunit gamma Neighboring gene putative uncharacterized protein YchS

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kinetics of membrane-bound nitrate reductase A from Escherichia coli with analogues of physiological electron donors--different reaction sites for menadiol and duroquinol. Giordani R, et al. Eur J Biochem, 1997 Dec 1. PMID 9428711
  2. Complete coordination of the four Fe-S centers of the beta subunit from Escherichia coli nitrate reductase. Physiological, biochemical, and EPR characterization of site-directed mutants lacking the highest or lowest potential [4Fe-4S] clusters. Guigliarelli B, et al. Biochemistry, 1996 Apr 16. PMID 8664273
  3. The iron-sulfur cluster composition of Escherichia coli nitrate reductase. Johnson MK, et al. J Biol Chem, 1985 May 10. PMID 2985594
  4. Cardiolipin-based respiratory complex activation in bacteria. Arias-Cartin R, et al. Proc Natl Acad Sci U S A, 2011 May 10. PMID 21518899, Free PMC Article
  5. chlC (nar) operon of Escherichia coli includes structural genes for alpha and beta subunits of nitrate reductase. Edwards ES, et al. J Bacteriol, 1983 Mar. PMID 6298188, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of the role of the FS0 cluster of Escherichia coli nitrate reductase A (NarGHI) in enzyme maturation
    Title: Protein crystallography reveals a role for the FS0 cluster of Escherichia coli nitrate reductase A (NarGHI) in enzyme maturation.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Roles of the narJ and narI gene products in the expression of nitrate reductase in Escherichia coli.
  3. molecular characterization of a quinol binding and oxidation site (Q-site) in NarGHI
    Title: Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nitrate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables nitrate reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaerobic electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within anaerobic respiration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in nitrate assimilation IEA
Inferred from Electronic Annotation
more info
  
involved_in nitrate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nitrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nitrate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NarGHI complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NarGHI complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nitrate reductase complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nitrate reductase A subunit beta
NP_415743.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1283604..1285142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415743.1 nitrate reductase A subunit beta [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415743.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1JA46, A0A3Y4XUS8, A0A6C9QI37, A0A828AEK9, W1X1G4
    Conserved Domains (1) summary
    COG1140
    Location:1 → 512
    NarY; Nitrate reductase beta subunit [Energy production and conversion, Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version

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