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narG nitrate reductase A subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945782, updated on 4-Apr-2024

Summary

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Gene symbol
narG
Gene description
nitrate reductase A subunit alpha
Primary source
ASAP:ABE-0004119
Locus tag
b1224
See related
ECOCYC:EG10638
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
chlC; ECK1218; narC
Summary
Induced by anaerobiosis plus nitrate. [More information is available at EcoGene: EG10638]. The subunit of nitrate reductase A is the actual site of nitrate reduction and also contains the molybdenum cofactor . [More information is available at EcoCyc: EG10638].
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Genomic context

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Sequence:
NC_000913.3 (1279864..1283607)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator NarL Neighboring gene sensor histidine kinase NarX Neighboring gene nitrate:nitrite antiporter NarK Neighboring gene ncRNA Neighboring gene nitrate reductase A subunit beta Neighboring gene nitrate reductase 1 molybdenum cofactor assembly chaperone Neighboring gene nitrate reductase A subunit gamma

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Respiratory nitrate reductase of Escherichia coli. Sequence identification of the large subunit gene. McPherson MJ, et al. FEBS Lett, 1984 Nov 19. PMID 6094247
  2. Ubisemiquinone in membranes from Escherichia coli. Hamilton JA, et al. Biochem J, 1970 Jan. PMID 4313116, Free PMC Article
  3. Delineation of two distinct regulatory domains in the 5' region of the nar operon of Escherichia coli. Li S, et al. J Bacteriol, 1985 Oct. PMID 2995309, Free PMC Article
  4. Cardiolipin-based respiratory complex activation in bacteria. Arias-Cartin R, et al. Proc Natl Acad Sci U S A, 2011 May 10. PMID 21518899, Free PMC Article
  5. Basis of recognition between the NarJ chaperone and the N-terminus of the NarG subunit from Escherichia coli nitrate reductase. Zakian S, et al. FEBS J, 2010 Apr. PMID 20236317

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of the role of the FS0 cluster of Escherichia coli nitrate reductase A (NarGHI) in enzyme maturation
    Title: Protein crystallography reveals a role for the FS0 cluster of Escherichia coli nitrate reductase A (NarGHI) in enzyme maturation.
  2. Conversion of tryptophan and sodium nitrate into 3-nitrosoindole derivatives requires functional genes for trytophanase (tnaA), a tryptophan permease (tnaB), and a nitrate reductase (narG).
    Title: Production of 3-nitrosoindole derivatives by Escherichia coli during anaerobic growth.
  3. NarJ associated with a peptide of the first 50 residues of nitrate reductase catalytic subunit NarG.
    Title: In vivo associations of Escherichia coli NarJ with a peptide of the first 50 residues of nitrate reductase catalytic subunit NarG.
  4. N-terminus verified by Edman degradation on mature peptide
    Title: Roles of the narJ and narI gene products in the expression of nitrate reductase in Escherichia coli.
  5. molecular characterization of a quinol binding and oxidation site (Q-site) in NarGHI
    Title: Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin cofactor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molybdopterin cofactor binding IEA
Inferred from Electronic Annotation
more info
  
enables nitrate reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nitrate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables nitrate reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaerobic electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within anaerobic respiration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular respiration IEA
Inferred from Electronic Annotation
more info
  
involved_in nitrate assimilation IEA
Inferred from Electronic Annotation
more info
  
involved_in nitrate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nitrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nitrate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NarGHI complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NarGHI complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nitrate reductase complex IEA
Inferred from Electronic Annotation
more info
  
part_of oxidoreductase complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nitrate reductase A subunit alpha
NP_415742.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1279864..1283607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415742.1 nitrate reductase A subunit alpha [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415742.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3Z6GAE9, A0A6N8QVM6
    Conserved Domains (1) summary
    TIGR01580
    Location:2 → 1235
    narG; respiratory nitrate reductase, alpha subunit
Nucleotide Protein
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