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pgsA CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945791, updated on 2-May-2024

Summary

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Gene symbol
pgsA
Gene description
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Primary source
ASAP:ABE-0006367
Locus tag
b1912
See related
ECOCYC:EG10706
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1911
Summary
Overexpression causes filamentous biofilm formation. [More information is available at EcoGene: EG10706].
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Genomic context

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Sequence:
NC_000913.3 (1992269..1992817, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Cys Neighboring gene tRNA-Gly Neighboring gene UvrABC excision nuclease subunit C Neighboring gene DNA-binding transcriptional activator UvrY Neighboring gene protein YecU Neighboring gene DUF2594 domain-containing protein YecF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activation of the Cpx phosphorelay signal transduction system in acidic phospholipid-deficient pgsA mutant cells of Escherichia coli. Itou A, et al. Biochem Biophys Res Commun, 2012 May 4. PMID 22503979
  2. Phosphatidic acid and N-acylphosphatidylethanolamine form membrane domains in Escherichia coli mutant lacking cardiolipin and phosphatidylglycerol. Mileykovskaya E, et al. J Biol Chem, 2009 Jan 30. PMID 19049984, Free PMC Article
  3. Display of active enzymes on the cell surface of Escherichia coli using PgsA anchor protein and their application to bioconversion. Narita J, et al. Appl Microbiol Biotechnol, 2006 May. PMID 16133338
  4. Dispensable nature of phosphatidylglycerol in Escherichia coli: dual roles of anionic phospholipids. Matsumoto K. Mol Microbiol, 2001 Mar. PMID 11260460
  5. Viability of an Escherichia coli pgsA null mutant lacking detectable phosphatidylglycerol and cardiolipin. Kikuchi S, et al. J Bacteriol, 2000 Jan. PMID 10629182, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cpx system is activated also in a pgsA mutant.
    Title: Activation of the Cpx phosphorelay signal transduction system in acidic phospholipid-deficient pgsA mutant cells of Escherichia coli.
  2. In the Escherichia coli pgsA null mutant, which lacks the major acidic phospholipids, the Rcs phosphorelay signal transduction system is activated, causing thermosensitive growth.
    Title: RcsA-dependent and -independent growth defects caused by the activated Rcs phosphorelay system in the Escherichia coli pgsA null mutant.
  3. The development of a novel Escherichia coli cell surface display system by employing PgsA as an anchoring motif is reported.
    Title: Display of active enzymes on the cell surface of Escherichia coli using PgsA anchor protein and their application to bioconversion.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycerophospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
NP_416422.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1992269..1992817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416422.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416422.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AJC9
    Conserved Domains (1) summary
    PRK10832
    Location:1 → 182
    PRK10832; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Nucleotide Protein
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Gene LinkOut

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