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clsA cardiolipin synthase A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945821, updated on 4-Apr-2024

Summary

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Gene symbol
clsA
Gene description
cardiolipin synthase A
Primary source
ASAP:ABE-0004186
Locus tag
b1249
See related
ECOCYC:EG11608
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cls; ECK1243; nov; yciJ
Summary
Overexpression causes filamentous biofilm formation. [More information is available at EcoGene: EG11608].
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Genomic context

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Sequence:
NC_000913.3 (1307185..1308645, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene murein tripeptide ABC transporter/oligopeptide ABC transporter ATP binding subunit OppD Neighboring gene murein tripeptide ABC transporter/oligopeptide ABC transporter ATP binding subunit OppF Neighboring gene DUF440 domain-containing protein YciU Neighboring gene uncharacterized protein YciY Neighboring gene K(+) channel Kch

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. E. coli cardiolipin synthase: function of N-terminal conserved residues. Quigley BR, et al. Biochim Biophys Acta, 2009 Oct. PMID 19341704
  2. Active increase in cardiolipin synthesis in the stationary growth phase and its physiological significance in Escherichia coli. Hiraoka S, et al. FEBS Lett, 1993 Dec 27. PMID 8262233
  3. The effects of phosphoglycerides on Escherichia coli cardiolipin synthase. Ragolia L, et al. Biochim Biophys Acta, 1994 Oct 6. PMID 7918616
  4. Nucleotide sequence, mutational analysis, transcriptional start site, and product analysis of nov, the gene which affects Escherichia coli K-12 resistance to the gyrase inhibitor novobiocin. Ivanisevic R, et al. J Bacteriol, 1995 Apr. PMID 7896699, Free PMC Article
  5. Identity of the Escherichia coli cls and nov genes. Tropp BE, et al. J Bacteriol, 1995 Sep. PMID 7665497, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results have demonstrated that ClsA is able to produce phosphatidylalcohols in the presence of a foreign lipid class, but not when only endogenous phospholipids are present.
    Title: Cardiolipin synthases of Escherichia coli have phospholipid class specific phospholipase D activity dependent on endogenous and foreign phospholipids.
  2. this study provides new information regarding the structure, membrane topology and subcellular localization of ClsA, revealing that targeted cardiolilin (CL) synthesis may contribute to the polar localization of CL, ClsA and ProP.
    Title: Cardiolipin synthase A colocalizes with cardiolipin and osmosensing transporter ProP at the poles of Escherichia coli cells.
  3. Data indicate that the cardiolipin synthase DeltaclsABC mutant (clsA, clsB(ybhO) and clsC (ymdC))nlacks detectible cardiolipin (CL) regardless of growth phase or growth conditions.
    Title: Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cardiolipin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cardiolipin synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cardiolipin synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cardiolipin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiolipin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiolipin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell pole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cardiolipin synthase A
NP_415765.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1307185..1308645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415765.1 cardiolipin synthase A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415765.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9A900, A0A5B9AN58
    Conserved Domains (1) summary
    PRK01642
    Location:5 → 486
    cls; cardiolipin synthetase; Reviewed
Nucleotide Protein
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