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purU formyltetrahydrofolate deformylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945827, updated on 6-Oct-2023

Summary

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Gene symbol
purU
Gene description
formyltetrahydrofolate deformylase
Primary source
ASAP:ABE-0004138
Locus tag
b1232
See related
ECOCYC:EG11819
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1227; tgs; ychI
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Genomic context

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Sequence:
NC_000913.3 (1287782..1288624, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Tyr Neighboring gene tRNA-Tyr Neighboring gene NTF2-like domain-containing protein YchJ Neighboring gene putative patatin-like phospholipase RssA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Assembly of an active enzyme by the linkage of two protein modules. Nixon AE, et al. Proc Natl Acad Sci U S A, 1997 Feb 18. PMID 9037007, Free PMC Article
  2. Genetic map of the tyrT region of Escherichia coli from 27.1 to 27.7 minutes based exclusively on sequence data. Bösl MR. J Bacteriol, 1993 Dec. PMID 8244954, Free PMC Article
  3. A novel RNA product of the tyrT operon of Escherichia coli. Bösl M, et al. Nucleic Acids Res, 1991 Nov 11. PMID 1840671, Free PMC Article
  4. The tyrT locus of Escherichia coli exhibits a regulatory function for glycine metabolism. Michelsen U, et al. J Bacteriol, 1989 Nov. PMID 2681148, Free PMC Article
  5. Organization and functions of genes in the upstream region of tyrT of Escherichia coli: phenotypes of mutants with partial deletion of a new gene (tgs). Bösl M, et al. J Bacteriol, 1994 Jan. PMID 8282700, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: purU, a source of formate for purT-dependent phosphoribosyl-N-formylglycinamide synthesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables formyltetrahydrofolate deformylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables formyltetrahydrofolate deformylase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within one-carbon metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein hexamerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
formyltetrahydrofolate deformylase
NP_415748.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1287782..1288624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415748.1 formyltetrahydrofolate deformylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415748.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AJA6
    Conserved Domains (1) summary
    PRK06027
    Location:1 → 280
    purU; formyltetrahydrofolate deformylase; Reviewed
Nucleotide Protein
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