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add adenosine deaminase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945851, updated on 25-Jan-2024

Summary

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Gene symbol
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Gene description
adenosine deaminase
Primary source
ASAP:ABE-0005435
Locus tag
b1623
See related
ECOCYC:EG10030
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1618
Summary
Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG10030].
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Genomic context

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Sequence:
NC_000913.3 (1702233..1703234)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PTS enzyme IIBC component MalX Neighboring gene negative regulator of MalT activity/cystathionine beta-lyase Neighboring gene putative oxidoreductase YdgJ Neighboring gene beta-lactam resistance protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Investigation of various genotype characteristics for inosine accumulation in Escherichia coli W3110. Matsui H, et al. Biosci Biotechnol Biochem, 2001 Mar. PMID 11330670
  2. [Phenotypic manifestation of the pnd mutation, which promotes purine nucleoside cleavage by Escherichia coli K-12 cells, in the genome of strains defective in the metabolism of nucleic acid precursors]. Kocharian ShM, et al. Genetika, 1981. PMID 7014363
  3. Escherichia coli mutants with altered control of alcohol dehydrogenase and nitrate reductase. Clark D, et al. J Bacteriol, 1980 Jan. PMID 6986356, Free PMC Article
  4. Substrate binding by adenosine deaminase. Specificity, pH dependence, and competition by mercurials. Wolfenden R, et al. J Biol Chem, 1967 Mar 10. PMID 5335916
  5. Induction of adenosine deaminase in Escherichia coli. Remy CN, et al. J Bacteriol, 1968 Jul. PMID 4874315, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2'-deoxyadenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenosine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenosine deaminase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in adenosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adenosine catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within hypoxanthine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hypoxanthine salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hypoxanthine salvage IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in inosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within purine nucleotide interconversion IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within purine nucleotide salvage IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in purine ribonucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within purine ribonucleoside monophosphate biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenosine deaminase
NP_416140.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1702233..1703234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416140.1 adenosine deaminase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416140.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9B1B4, A0A8T3UKR8
    Conserved Domains (1) summary
    PRK09358
    Location:1 → 332
    PRK09358; adenosine deaminase; Provisional
Nucleotide Protein
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Research Materials