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pgpB phosphatidylglycerophosphatase B [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945863, updated on 23-Nov-2023

Summary

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Gene symbol
pgpB
Gene description
phosphatidylglycerophosphatase B
Primary source
ASAP:ABE-0004294
Locus tag
b1278
See related
ECOCYC:EG10705
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1273
Summary
The pgpB gene is nonessential, but is synthetically lethal with a bacA ybjG double mutant, due to its UppP activity. ybjG, pgpB, and lpxT are paralogs. [More information is available at EcoGene: EG10705]. PgpB is one of three phosphatidylglycerophosphatase (PGP-ase) activities in Escherichia coli. [More information is available at EcoCyc: EG10705].
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Genomic context

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Sequence:
NC_000913.3 (1339330..1340094)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene aconitate hydratase 1 Neighboring gene GTP cyclohydrolase 2 Neighboring gene lipopolysaccharide assembly protein A Neighboring gene lipopolysaccharide assembly protein B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane. Tong S, et al. J Biol Chem, 2016 Aug 26. PMID 27405756, Free PMC Article
  2. Substrate specificity and membrane topology of Escherichia coli PgpB, an undecaprenyl pyrophosphate phosphatase. Touzé T, et al. J Biol Chem, 2008 Jun 13. PMID 18411271
  3. Membrane-bound phosphatases in Escherichia coli: sequence of the pgpB gene and dual subcellular localization of the pgpB product. Icho T. J Bacteriol, 1988 Nov. PMID 2846511, Free PMC Article
  4. The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity. Dillon DA, et al. J Biol Chem, 1996 Nov 29. PMID 8940025
  5. Multiple genes for membrane-bound phosphatases in Escherichia coli and their action on phospholipid precursors. Icho T, et al. J Bacteriol, 1983 Feb. PMID 6296050, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These studies reveal new mechanisms of lipid substrate selection and catalysis by PgpB and suggest that the enzyme rests in a PE-stabilized state in the bilayer.
    Title: Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane.
  2. analysis of substrate specificity and membrane topology of Escherichia coli PgpB, an undecaprenyl pyrophosphate phosphatase
    Title: Substrate specificity and membrane topology of Escherichia coli PgpB, an undecaprenyl pyrophosphate phosphatase.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables diacylglycerol diphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylglycerophosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylglycerophosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables undecaprenyl-diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables undecaprenyl-diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables undecaprenyl-diphosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within glycerophospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell outer membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylglycerophosphatase B
NP_415794.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1339330..1340094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415794.1 phosphatidylglycerophosphatase B [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415794.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376THP3, A0A895NV98
    Conserved Domains (1) summary
    PRK10699
    Location:1 → 244
    PRK10699; phosphatidylglycerophosphatase B; Provisional
Nucleotide Protein
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