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puuD gamma-glutamyl-gamma-aminobutyrate hydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945882, updated on 4-Apr-2024

Summary

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Gene symbol
puuD
Gene description
gamma-glutamyl-gamma-aminobutyrate hydrolase
Primary source
ASAP:ABE-0004369
Locus tag
b1298
See related
ECOCYC:G6645
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1293; ycjL
Summary
C114 is the active site. [More information is available at EcoGene: EG13909]. PuuD was identified as the -glutamyl--aminobutyrate hydrolase in a putrescine utilization pathway. [More information is available at EcoCyc: G6645].
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Genomic context

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Sequence:
NC_000913.3 (1361120..1361884)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putrescine:H(+) symporter PuuP Neighboring gene protein YmjE Neighboring gene glutamate-putrescine ligase Neighboring gene DNA-binding transcriptional repressor PuuR Neighboring gene gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12. Kurihara S, et al. FEMS Microbiol Lett, 2006 Mar. PMID 16499623
  2. A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12. Kurihara S, et al. J Biol Chem, 2005 Feb 11. PMID 15590624
  3. Escherichia coli transcriptome dynamics during the transition from anaerobic to aerobic conditions. Partridge JD, et al. J Biol Chem, 2006 Sep 22. PMID 16857675
  4. MEROPS: the peptidase database. Rawlings ND, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381862, Free PMC Article
  5. Large-scale identification of protein-protein interaction of Escherichia coli K-12. Arifuzzaman M, et al. Genome Res, 2006 May. PMID 16606699, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  2. findings that the puuD-deficient strain accumulated gamma-glutamyl-gamma-aminobutyrate (gamma-Glu-GABA) and could not grow on putrescine as a sole nitrogen source indicate that PuuD is physiologically important as a gamma-Glu-GABA hydrolase
    Title: Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables gamma-glutamyl-gamma-aminobutyrate hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gamma-glutamyl-gamma-aminobutyrate hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables gamma-glutamyl-gamma-aminobutyrate hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in polyamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in putrescine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within putrescine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
gamma-glutamyl-gamma-aminobutyrate hydrolase
NP_415814.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1361120..1361884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415814.4 gamma-glutamyl-gamma-aminobutyrate hydrolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415814.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7A6UDL7
    Conserved Domains (1) summary
    PRK11366
    Location:1 → 254
    puuD; gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional
Nucleotide Protein
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Gene LinkOut

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