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feaB phenylacetaldehyde dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945933, updated on 4-Apr-2024

Summary

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Gene symbol
feaB
Gene description
phenylacetaldehyde dehydrogenase
Primary source
ASAP:ABE-0004637
Locus tag
b1385
See related
ECOCYC:G7961
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1382; padA; ydbG
Summary
Phenylacetaldehyde dehydrogenase is a dimer in solution . [More information is available at EcoCyc: G7961].
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Genomic context

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Sequence:
NC_000913.3 (1447519..1449018)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1318 domain-containing protein YdbL Neighboring gene DNA-binding transcriptional activator FeaR Neighboring gene copper-containing amine oxidase Neighboring gene fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. 2-Phenylethylamine catabolism by Escherichia coli K12. Parrott S, et al. J Gen Microbiol, 1987 Feb. PMID 3309152
  2. Chemotaxis of Escherichia coli to norepinephrine (NE) requires conversion of NE to 3,4-dihydroxymandelic acid. Pasupuleti S, et al. J Bacteriol, 2014 Dec. PMID 25182492, Free PMC Article
  3. Finely tuned regulation of the aromatic amine degradation pathway in Escherichia coli. Zeng J, et al. J Bacteriol, 2013 Nov. PMID 24013633, Free PMC Article
  4. Escherichia coli NsrR regulates a pathway for the oxidation of 3-nitrotyramine to 4-hydroxy-3-nitrophenylacetate. Rankin LD, et al. J Bacteriol, 2008 Sep. PMID 18658270, Free PMC Article
  5. Characterization of E. coli tetrameric aldehyde dehydrogenases with atypical properties compared to other aldehyde dehydrogenases. Rodríguez-Zavala JS, et al. Protein Sci, 2006 Jun. PMID 16731973, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Only strains that produce TynA and FeaB converting norepinephrine to 3,4-dihydroxymandelic acid xhibited chemotaxis toward norepinephrine and 3,4-dihydroxymandelic acid is sensed by the serine chemoreceptor Tsr.
    Title: Chemotaxis of Escherichia coli to norepinephrine (NE) requires conversion of NE to 3,4-dihydroxymandelic acid.
  2. Using genetic, biochemical and computational approaches, authors show that the FeaR binding site is a TGNCA-N8-AAA motif that occurs in 2 copies in the tynA and feaB promoters.
    Title: Finely tuned regulation of the aromatic amine degradation pathway in Escherichia coli.
  3. N-terminus verified by Edman degradation on complete protein
    Title: Molecular characterization of PadA, a phenylacetaldehyde dehydrogenase from Escherichia coli.
  4. phenylacetaldehyde dehydrogenases (PAD) used both NAD+ and NADP+ but with a clear preference for NAD
    Title: Characterization of E. coli tetrameric aldehyde dehydrogenases with atypical properties compared to other aldehyde dehydrogenases.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4-hydroxyphenylacetaldehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldehyde dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables phenylacetaldehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phenylacetaldehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phenylacetaldehyde dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within 4-nitrophenol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within NAD biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phenylethylamine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phenylacetaldehyde dehydrogenase
NP_415903.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1447519..1449018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415903.4 phenylacetaldehyde dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415903.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1X3J1L1, A0A1X3JHW4
    Conserved Domains (1) summary
    cd07113
    Location:21 → 499
    ALDH_PADH_NahF; Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like
Nucleotide Protein
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