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abgB p-aminobenzoyl-glutamate hydrolase subunit B [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945950, updated on 11-Apr-2024

Summary

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Gene symbol
abgB
Gene description
p-aminobenzoyl-glutamate hydrolase subunit B
Primary source
ASAP:ABE-0004491
Locus tag
b1337
See related
ECOCYC:G6669
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1333; ydaI
Summary
abgAB expression is required for catabolism to feed p-aminobenzoate auxotrophs (Hussein, 1998; Carter, 2007). [More information is available at EcoGene: EG13351]. AbgB appears to have detectable p-aminobenzoyl-glutamate hydrolase activity but is not essential for use of exogenously added p-aminobenzoyl-glutamate . [More information is available at EcoCyc: G6669].
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Genomic context

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Sequence:
NC_000913.3 (1401810..1403255, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene methylated-DNA--[protein]-cysteine S-methyltransferase Neighboring gene p-aminobenzoyl glutamate:H(+) symporter Neighboring gene p-aminobenzoyl-glutamate hydrolase subunit A Neighboring gene putative LysR-type DNA-binding transcriptional regulator AbgR Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD). Bartsch K, et al. J Bacteriol, 1990 Dec. PMID 2254272, Free PMC Article
  2. Purification and characterization of the folate catabolic enzyme p-aminobenzoyl-glutamate hydrolase from Escherichia coli. Green JM, et al. J Bacteriol, 2010 May. PMID 20190044, Free PMC Article
  3. Escherichia coli abg genes enable uptake and cleavage of the folate catabolite p-aminobenzoyl-glutamate. Carter EL, et al. J Bacteriol, 2007 May. PMID 17307853, Free PMC Article
  4. Characterization of mutations that allow p-aminobenzoyl-glutamate utilization by Escherichia coli. Hussein MJ, et al. J Bacteriol, 1998 Dec. PMID 9829935, Free PMC Article
  5. MEROPS: the peptidase database. Rawlings ND, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381862, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables para-aminobenzoyl-glutamate hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables para-aminobenzoyl-glutamate hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables para-aminobenzoyl-glutamate hydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in folic acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in folic acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within folic acid catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
p-aminobenzoyl-glutamate hydrolase subunit B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1401810..1403255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415853.1 p-aminobenzoyl-glutamate hydrolase subunit B [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415853.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7K1X1
    Conserved Domains (1) summary
    cd05673
    Location:12 → 458
    M20_Acy1L2_AbgB; M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily
Nucleotide Protein
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