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paaZ fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945954, updated on 6-Oct-2023

Summary

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Gene symbol
paaZ
Gene description
fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase
Primary source
ASAP:ABE-0004644
Locus tag
b1387
See related
ECOCYC:G6708
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1384; maoC; ydbN
Summary
MaoC is involved in supplying (R)-3-hydroxyacyl-CoA from the beta-oxidation pathway to the PHA biosynthetic pathway, in fadB mutants. [More information is available at EcoGene: EG13735]. PaaZ is a putative ring-cleavage enzyme involved in phenylacetate catabolism . [More information is available at EcoCyc: G6708].
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Genomic context

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Sequence:
NC_000913.3 (1451597..1453642, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phenylacetaldehyde dehydrogenase Neighboring gene copper-containing amine oxidase Neighboring gene phenylacetyl-CoA 1,2-epoxidase, monooxygenase subunit Neighboring gene phenylacetyl-CoA 1,2-epoxidase subunit B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway. Sathyanarayanan N, et al. Nat Commun, 2019 Sep 11. PMID 31511507, Free PMC Article
  2. Studies on the mechanism of ring hydrolysis in phenylacetate degradation: a metabolic branching point. Teufel R, et al. J Biol Chem, 2011 Apr 1. PMID 21296885, Free PMC Article
  3. A monoamine-regulated Klebsiella aerogenes operon containing the monoamine oxidase structural gene (maoA) and the maoC gene. Sugino H, et al. J Bacteriol, 1992 Apr. PMID 1556068, Free PMC Article
  4. The monoamine regulon including syntheses of arylsulfatase and monoamine oxidase in bacteria. Murooka Y, et al. Biosci Biotechnol Biochem, 1996 Jun. PMID 8695909
  5. Identification and characterization of a new enoyl coenzyme A hydratase involved in biosynthesis of medium-chain-length polyhydroxyalkanoates in recombinant Escherichia coli. Park SJ, et al. J Bacteriol, 2003 Sep. PMID 12949091, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables enoyl-CoA hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ether hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylacetate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phenylacetate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phenylacetate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase
NP_415905.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1451597..1453642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415905.1 fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415905.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M9WVP1
    Conserved Domains (1) summary
    PRK11563
    Location:1 → 674
    PRK11563; bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional
Nucleotide Protein
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