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paaC phenylacetyl-CoA 1,2-epoxidase, structural subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945956, updated on 23-Nov-2023

Summary

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Gene symbol
paaC
Gene description
phenylacetyl-CoA 1,2-epoxidase, structural subunit
Primary source
ASAP:ABE-0004653
Locus tag
b1390
See related
ECOCYC:G6711
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1387; ydbP
Summary
PaaABCDE is a multi-subunit oxygenase that hydroxylates phenylacetyl-CoA. [More information is available at EcoGene: EG13737]. PaaA, PaaB, PaaC, and PaaD are predicted to be subunits of a phenylacetate-CoA oxygenase involved in phenylacetate catabolism . [More information is available at EcoCyc: G6711].
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Genomic context

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Sequence:
NC_000913.3 (1455164..1455910)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phenylacetyl-CoA 1,2-epoxidase, monooxygenase subunit Neighboring gene phenylacetyl-CoA 1,2-epoxidase subunit B Neighboring gene phenylacetate degradation protein Neighboring gene phenylacetyl-CoA 1,2-epoxidase, reductase subunit Neighboring gene putative 2,3-dehydroadipyl-CoA hydratase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex. Grishin AM, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Sep 1. PMID 20823522, Free PMC Article
  2. Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex. Grishin AM, et al. J Biol Chem, 2011 Mar 25. PMID 21247899, Free PMC Article
  3. Genetic characterization of the phenylacetyl-coenzyme A oxygenase from the aerobic phenylacetic acid degradation pathway of Escherichia coli. Fernández C, et al. Appl Environ Microbiol, 2006 Nov. PMID 16997993, Free PMC Article
  4. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
  5. Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Zhang N, et al. Proteomics, 2007 Feb. PMID 17309111

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PaaAC, which catalyzes the hydroxylation reaction, was purified and crystallized in the absence of a bound ligand as well as in complexes with CoA, 3-hydroxybutyryl-CoA, benzoyl-CoA and the true substrate phenylacetyl-CoA
    Title: Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in phenylacetate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylacetate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phenylacetate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylacetate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
part_of phenylacetyl-CoA 1,2-epoxidase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
phenylacetyl-CoA 1,2-epoxidase, structural subunit
NP_415908.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1455164..1455910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415908.1 phenylacetyl-CoA 1,2-epoxidase, structural subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415908.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5C9AAD3
    Conserved Domains (1) summary
    TIGR02158
    Location:11 → 248
    PA_CoA_Oxy3; phenylacetate-CoA oxygenase, PaaI subunit
Nucleotide Protein
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