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paaK phenylacetate-CoA ligase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945963, updated on 2-May-2024

Summary

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Gene symbol
paaK
Gene description
phenylacetate-CoA ligase
Primary source
ASAP:ABE-0004671
Locus tag
b1398
See related
ECOCYC:G6719
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1395
Summary
PaaK is a phenylacetate-CoA ligase (shown in Escherichia coli W) that acts at the first step in an aerobic pathway of phenylacetate degradation . [More information is available at EcoCyc: G6719].
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Genomic context

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Sequence:
NC_000913.3 (1462125..1463438)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-hydroxyadipyl-CoA dehydrogenase Neighboring gene phenylacetyl-CoA thioesterase Neighboring gene beta-ketoadipyl-CoA thiolase Neighboring gene DNA-binding transcriptional repressor PaaX Neighboring gene 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA thioesterase Neighboring gene uncharacterized protein YnbG

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phenylacetate-coenzyme A ligase is induced during growth on phenylacetic acid in different bacteria of several genera. Vitovski S. FEMS Microbiol Lett, 1993 Mar 15. PMID 8472917
  2. Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli. Burlingame R, et al. J Bacteriol, 1983 Jul. PMID 6345502, Free PMC Article
  3. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
  4. Biochemical and molecular characterization of phenylacetate-coenzyme A ligase, an enzyme catalyzing the first step in aerobic metabolism of phenylacetic acid in Azoarcus evansii. El-Said Mohamed M. J Bacteriol, 2000 Jan. PMID 10629172, Free PMC Article
  5. Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. Ferrández A, et al. J Biol Chem, 2000 Apr 21. PMID 10766858

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CoA-ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables phenylacetate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables phenylacetate-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in phenylacetate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylacetate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
phenylacetate-CoA ligase
NP_415916.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1462125..1463438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415916.1 phenylacetate-CoA ligase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415916.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AA47
    Conserved Domains (1) summary
    TIGR02155
    Location:11 → 432
    PA_CoA_ligase; phenylacetate-CoA ligase
Nucleotide Protein
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