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mpaA murein tripeptide amidase A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945969, updated on 2-May-2024

Summary

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Gene symbol
mpaA
Gene description
murein tripeptide amidase A
Primary source
ASAP:ABE-0004450
Locus tag
b1326
See related
ECOCYC:G6662
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1322; ycjI
Summary
MpaA is a murein peptide amidase that may act with YcjG in murein recycling . [More information is available at EcoCyc: G6662].
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Genomic context

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Sequence:
NC_000913.3 (1389870..1390598, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator TyrR Neighboring gene lipid hydroperoxide peroxidase Neighboring gene L-Ala-D/L-Glu epimerase Neighboring gene putative uncharacterized protein YmjC Neighboring gene uncharacterized protein YmjD Neighboring gene putative hydrolase YcjY

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MpaA is a murein-tripeptide-specific zinc carboxypeptidase that functions as part of a catabolic pathway for peptidoglycan-derived peptides in γ-proteobacteria. Maqbool A, et al. Biochem J, 2012 Dec 15. PMID 22970852
  2. Identification of MpaA, an amidase in Escherichia coli that hydrolyzes the gamma-D-glutamyl-meso-diaminopimelate bond in murein peptides. Uehara T, et al. J Bacteriol, 2003 Jan. PMID 12511517, Free PMC Article
  3. Thioredoxin-linked "thiol peroxidase" from periplasmic space of Escherichia coli. Cha MK, et al. J Biol Chem, 1995 Dec 1. PMID 7499381
  4. How bacteria consume their own exoskeletons (turnover and recycling of cell wall peptidoglycan). Park JT, et al. Microbiol Mol Biol Rev, 2008 Jun. PMID 18535144, Free PMC Article
  5. MEROPS: the peptidase database. Rawlings ND, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381862, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables amidase activity IEA
Inferred from Electronic Annotation
more info
  
enables amidase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables murein tripeptide carboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables murein tripeptide carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall macromolecule catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in glycopeptide catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidoglycan catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peptidoglycan catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
murein tripeptide amidase A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1389870..1390598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415842.2 murein tripeptide amidase A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415842.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A775UVR7, A0A8S7TAP7
    Conserved Domains (1) summary
    PRK10602
    Location:1 → 237
    PRK10602; murein tripeptide amidase MpaA
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases